• Publications
  • Influence
Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC
Most human coronaviruses cause mild upper respiratory tract disease but may be associated with more severe pulmonary disease in immunocompromised individuals. However, SARS coronavirus caused severeExpand
  • 1,200
  • 94
  • PDF
Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study
Summary Background A new betacoronavirus—Middle East respiratory syndrome coronavirus (MERS-CoV)—has been identified in patientsExpand
  • 593
  • 38
  • PDF
Novel Hepatitis E Virus in Ferrets, the Netherlands
To the Editor: Hepatitis E virus (HEV), a member of the family Hepeviridae and the genus Hepevirus, is transmitted by the fecal–oral route and causes liver inflammation, which leads to mortalityExpand
  • 154
  • 14
  • PDF
Adenosine Deaminase Acts as a Natural Antagonist for Dipeptidyl Peptidase 4-Mediated Entry of the Middle East Respiratory Syndrome Coronavirus
ABSTRACT Middle East respiratory syndrome coronavirus (MERS-CoV) replicates in cells of different species using dipeptidyl peptidase 4 (DPP4) as a functional receptor. Here we show the resistance ofExpand
  • 126
  • 14
  • PDF
Exacerbated Innate Host Response to SARS-CoV in Aged Non-Human Primates
The emergence of viral respiratory pathogens with pandemic potential, such as severe acute respiratory syndrome coronavirus (SARS-CoV) and influenza A H5N1, urges the need for deciphering theirExpand
  • 227
  • 13
  • PDF
An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels
Coronaviruses in the Middle East Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe acute respiratory illness and kills about a third of people infected. The virus is common inExpand
  • 174
  • 13
  • PDF
Human Coronavirus EMC Does Not Require the SARS-Coronavirus Receptor and Maintains Broad Replicative Capability in Mammalian Cell Lines
ABSTRACT A new human coronavirus (hCoV-EMC) has emerged very recently in the Middle East. The clinical presentation resembled that of the severe acute respiratory syndrome (SARS) as encounteredExpand
  • 191
  • 12
  • PDF
Virus genomes reveal factors that spread and sustained the Ebola epidemic
We reconstruct the dispersal, proliferation and decline of Ebola virus throughout the region by analysing 1,610 Ebola virus genomes, which represent over 5% of the known cases. Expand
  • 237
  • 11
  • PDF
Human Picobirnaviruses Identified by Molecular Screening of Diarrhea Samples
ABSTRACT The global threat of (re)emerging infectious viruses requires a more effective approach regarding virus surveillance and diagnostic assays, as current diagnostics are often virus speciesExpand
  • 91
  • 7
Detection of novel divergent arenaviruses in boid snakes with inclusion body disease in The Netherlands.
Arenaviruses are bi-segmented negative-stranded RNA viruses, which were until recently only detected in rodents and humans. Now highly divergent arenaviruses have been identified in boid snakes withExpand
  • 71
  • 6