• Publications
  • Influence
Multicenter, placebo-controlled trial of lorcaserin for weight management.
BACKGROUND Lorcaserin is a selective serotonin 2C receptor agonist that could be useful in reducing body weight. METHODS In this double-blind clinical trial, we randomly assigned 3182 obese orExpand
  • 733
  • 50
  • PDF
The Human Serum Metabolome
Continuing improvements in analytical technology along with an increased interest in performing comprehensive, quantitative metabolic profiling, is leading to increased interest pressures within theExpand
  • 1,040
  • 45
  • PDF
Calorie Restriction Increases Muscle Mitochondrial Biogenesis in Healthy Humans
Background Caloric restriction without malnutrition extends life span in a range of organisms including insects and mammals and lowers free radical production by the mitochondria. However, theExpand
  • 637
  • 29
  • PDF
Increased visceral fat and decreased energy expenditure during the menopausal transition
Objective:This study assessed longitudinal changes in body composition, fat distribution and energy balance in perimenopausal women. We hypothesized that total fat and abdominal body fat wouldExpand
  • 565
  • 26
Alternate-day fasting in nonobese subjects: effects on body weight, body composition, and energy metabolism.
BACKGROUND Prolonged dietary restriction increases the life span in rodents. Some evidence suggests that alternate-day fasting may also prolong the life span. OBJECTIVE Our goal was to determineExpand
  • 249
  • 23
  • PDF
Comparison of weight-loss diets with different compositions of fat, protein, and carbohydrates.
BACKGROUND The possible advantage for weight loss of a diet that emphasizes protein, fat, or carbohydrates has not been established, and there are few studies that extend beyond 1 year. METHODS WeExpand
  • 1,120
  • 22
  • PDF
Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial.
CONTEXT Prolonged calorie restriction increases life span in rodents. Whether prolonged calorie restriction affects biomarkers of longevity or markers of oxidative stress, or reduces metabolic rateExpand
  • 755
  • 22
  • PDF
Human mesenchymal stem cells as an in vitro model for human adipogenesis.
OBJECTIVE To validate the human mesenchymal stem cells (hMSCs) as a new in vitro model for the study of human adipogenesis, to develop the optimal protocol for the differentiation of hMSCs intoExpand
  • 259
  • 22
Reduced Adipose Tissue Oxygenation in Human Obesity-Evidence for Rarefaction , Macrophage Chemotaxis and Inflammation without an Angiogenic Response
Objective: Based on rodent studies, we examined the hypothesis that increased adipose tissue mass in obesity without an adequate support of vascularization might lead to hypoxia, macrophageExpand
  • 428
  • 22
  • PDF
Randomized Placebo‐Controlled Clinical Trial of Lorcaserin for Weight Loss in Type 2 Diabetes Mellitus: The BLOOM‐DM Study
The BLOOM‐DM (Behavioral Modification and Lorcaserin for Obesity and Overweight Management in Diabetes Mellitus) study evaluated efficacy and safety of lorcaserin for weight loss in patients withExpand
  • 450
  • 21
  • PDF