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An investigation of the mobility separation of some peptide and protein ions using a new hybrid quadrupole/travelling wave IMS/oa-ToF instrument
Ion mobility coupled with mass spectrometry has evolved into a powerful analytical technique for investigating the gas-phase structures of biomolecules. Here we present the mobility separation ofExpand
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Improved System for Protein Engineering of the Hydroxylase Component of Soluble Methane Monooxygenase
ABSTRACT Soluble methane monooxygenase (sMMO) of Methylosinustrichosporium OB3b is a three-component oxygenase that catalyses the O2- and NAD(P)H-dependent oxygenation of methane and numerous otherExpand
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A comparison of labeling and label-free mass spectrometry-based proteomics approaches.
The proteome of the recently discovered bacterium Methylocella silvestris has been characterized using three profiling and comparative proteomics approaches. The organism has been grown on twoExpand
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Urbilaterian origin of paralogous GnRH and corazonin neuropeptide signalling pathways
Gonadotropin-releasing hormone (GnRH) is a key regulator of reproductive maturation in humans and other vertebrates. Homologs of GnRH and its cognate receptor have been identified inExpand
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Reticulomics: Protein-Protein Interaction Studies with Two Plasmodesmata-Localized Reticulon Family Proteins Identify Binding Partners Enriched at Plasmodesmata, Endoplasmic Reticulum, and the Plasma
Protein interactions for two plasmodesmata-localized reticulon proteins suggest that these proteins, in addition to a role in endoplasmic reticulum modeling, may play important roles in linking theExpand
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Characterization of phosphorylated peptides using traveling wave-based and drift cell ion mobility mass spectrometry.
Phosphorylation is one the most studied and important post translational modifications. Nano electrospray mass spectrometry coupled with traveling wave (T-Wave)-based ion mobility has been used toExpand
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Structural analysis of prion proteins by means of drift cell and traveling wave ion mobility mass spectrometry
The prion protein (PrP) is implicitly involved in the pathogenesis of transmissible spongiform encephalopathies (TSEs). The conversion of normal cellular PrP (PrPC), a protein that is predominantlyExpand
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Exploring the functional soil-microbe interface and exoenzymes through soil metaexoproteomics
Functionally important proteins at the interface of cell and soil are of potentially low abundance when compared with commonly recovered intracellular proteins. A novel approach was developed andExpand
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Substrate and stereochemical control of peptidoglycan crosslinking by transpeptidation by Escherichia coli PBP1B.
Penicillin binding proteins (PBPs) catalysing transpeptidation reactions that stabilize the peptidoglycan component of the bacterial cell wall are the targets of beta-lactams, the most clinicallyExpand
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Ion mobility mass spectrometry of proteins in a modified commercial mass spectrometer
Abstract Ion mobility has emerged as an important technique for determining biopolymer conformations in solvent free environments. These experiments have been nearly exclusively performed on homeExpand
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