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Introduction of a Composite Parameter to the Pharmacokinetics of Venlafaxine and its Active O‐Desmethyl Metabolite
Venlafaxine is a structurally novel, nontricyclic compound that is being evaluated for the treatment of various depressive disorders. A randomized three‐period crossover study was conducted to obtainExpand
Metabolic disposition of 14C-venlafaxine in mouse, rat, dog, rhesus monkey and man.
1. The metabolic disposition of venlafaxine has been studied in mouse, rat, dog, rhesus monkey and man after oral doses (22, 22, 2, and 10 mg/kg, and 50 mg, respectively) of 14C-venlafaxine as theExpand
High Performance Liquid Chromatographic Isolation, Spectroscopic Characterization, and Immunosuppressive Activities of Two Rapamycin Degradation Products
Abstract A high performance liquid chromatographic method has been developed for the isolation of two degradation products of rapamycin which is currently under development as an immunosuppressiveExpand
Pharmacokinetics of venlafaxine and O-desmethylvenlafaxine in laboratory animals.
1. The pharmacokinetics of venlafaxine have been evaluated in mouse, rat, dog and rhesus monkey after i.v. and/or i.g. doses of venlafaxine from 2 to 120 mg/kg either as single or repeated doses. 2.Expand
[14C]7-ethoxycoumarin metabolism by precision-cut rat hepatic slices.
The metabolism of [14C]7-ethoxycoumarin ([14C]7-EC) has been studied in rat liver slice cultures in vitro by using a direct radiometric high-pressure liquid chromatography method. [14C]7-EC wasExpand
The metabolic disposition of 14C-ciramadol in humans.
Twelve subjects received single 15 mg oral doses of 14C-ciramadol. Excretion of the dose occurred almost entirely by the renal route (93.5 +/- 11.7 (S.D.)% of the dose), and only 0.7 +/- 0.6% of theExpand
Diastereoisomeric glucuronides of oxazepam. Isolation and stereoselective enzymic hydrolysis.
Oxazepam glucuronide isolated from swine urine by previously published methods was separated into its diastereoisomers by ion-exchange chromatography on a preparative scale. QuantitativeExpand
Disposition and metabolism of lorazepam in the male rat.
The metabolic disposition of oxazepam in rats.
  • S. Sisenwine, C. Tio
  • Chemistry, Medicine
  • Drug metabolism and disposition: the biological…
  • 1986
The metabolic fate of oxazepam in the rat is more complex than in larger animal species. Condensation of the diazepinyl ring and phase 1 transformations which lead presumedly via an epoxide toExpand
The disposition of venlafaxine enantiomers in dogs, rats, and humans receiving venlafaxine.
A stereospecific high-performance liquid chromatographic (HPLC) method was developed for the quantitation of the enantiomers of venlafaxine, an antidepressant, in dog, rat, and human plasma. TheExpand