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Introduction of a Composite Parameter to the Pharmacokinetics of Venlafaxine and its Active O‐Desmethyl Metabolite
- K. Klamerus, K. Moloney, R. Rudolph, S. Sisenwine, W. Jusko, S. Chiang
- MedicineJournal of clinical pharmacology
- 1 August 1992
Venlafaxine is a structurally novel, nontricyclic compound that is being evaluated for the treatment of various depressive disorders. A randomized three‐period crossover study was conducted to obtain…
Metabolic disposition of 14C-venlafaxine in mouse, rat, dog, rhesus monkey and man.
- S. R. Howell, G. E. Husbands, J. Scatina, S. Sisenwine
- Biology, ChemistryXenobiotica; the fate of foreign compounds in…
- 1993
TLDR
High Performance Liquid Chromatographic Isolation, Spectroscopic Characterization, and Immunosuppressive Activities of Two Rapamycin Degradation Products
- C. P. Wang, Kelvin W. Chan, R. Schiksnis, J. Scatina, S. Sisenwine
- Chemistry
- 1 September 1994
Abstract A high performance liquid chromatographic method has been developed for the isolation of two degradation products of rapamycin which is currently under development as an immunosuppressive…
Diastereoisomeric glucuronides of oxazepam. Isolation and stereoselective enzymic hydrolysis.
- H. W. Ruelius, C. Tio, J. Knowles, S. L. McHugh, R. Schillings, S. Sisenwine
- Chemistry, BiologyDrug metabolism and disposition: the biological…
- 1979
TLDR
Pharmacokinetics of venlafaxine and O-desmethylvenlafaxine in laboratory animals.
- S. R. Howell, D. Hicks, J. Scatina, S. Sisenwine
- Biology, ChemistryXenobiotica; the fate of foreign compounds in…
- 1994
TLDR
[14C]7-ethoxycoumarin metabolism by precision-cut rat hepatic slices.
- S. Ball, V. Thiel, J. Scatina
- Biology, ChemistryDrug metabolism and disposition: the biological…
- 1 April 1996
TLDR
Clinical pharmacokinetics of lorazepam. I. Absorption and disposition of oral 14C-lorazepam.
- D. Greenblatt, R. Schillings, H. W. Ruelius
- MedicineClinical pharmacology and therapeutics
- 1976
TLDR
The metabolic disposition of 14C-ciramadol in humans.
- S. Sisenwine, A. Liu, C. Tio, H. Kimmel, G. Freeland
- Medicine, BiologyXenobiotica; the fate of foreign compounds in…
- 1986
TLDR
Disposition and metabolism of lorazepam in the male rat.
- R. Schillings, S. Sisenwine, H. W. Ruelius
- BiologyDrug metabolism and disposition: the biological…
- 1 September 1977
The metabolic disposition of oxazepam in rats.
- S. Sisenwine, C. Tio
- Biology, ChemistryDrug metabolism and disposition: the biological…
- 1986
TLDR
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