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Identification of a cancer stem cell in human brain tumors.
Most current research on human brain tumors is focused on the molecular and cellular analysis of the bulk tumor mass. However, there is overwhelming evidence in some malignancies that the tumor clone… Expand
Cancer stem cells in nervous system tumors
Most current research on human brain tumors is focused on the molecular and cellular analysis of the bulk tumor mass. However, evidence in leukemia and more recently in solid tumors such as breast… Expand
Sonic hedgehog regulates Bmi1 in human medulloblastoma brain tumor-initiating cells
Bmi1 is a key stem cell regulatory gene implicated in the pathogenesis of many aggressive cancers, including medulloblastoma. Overexpression of Bmi1 promotes cell proliferation and is required for… Expand
Investigating the Link between Molecular Subtypes of Glioblastoma, Epithelial-Mesenchymal Transition, and CD133 Cell Surface Protein
In this manuscript, we use genetic data to provide a three-faceted analysis on the links between molecular subclasses of glioblastoma, epithelial-to-mesenchymal transition (EMT) and CD133 cell… Expand
Childhood Cerebellar Tumors Mirror Conserved Fetal Transcriptional Programs
The study of the origin and development of cerebellar tumours has been hampered by the complexity and heterogeneity of cerebellar cells that change over the course of development. We used single-cell… Expand
Chronic Subdural Hematoma Management: A Systematic Review and Meta-analysis of 34829 Patients
Objective:To compare the efficacy and safety of multiple treatment modalities for the management of chronic subdural hematoma (CSDH) patients. Background:Current management strategies of CSDHs remain… Expand
EMT: Mechanisms and therapeutic implications
- M. Singh, Nicolas Yelle, C. Venugopal, S. Singh
- Medicine, Biology
- Pharmacology & therapeutics
- 20 August 2017
Abstract Metastasis, the dissemination of cancer cells from primary tumors, represents a major hurdle in the treatment of cancer. The epithelial‐mesenchymal transition (EMT) has been studied in… Expand
Biopsy versus partial versus gross total resection in older patients with high-grade glioma: a systematic review and meta-analysis.
BACKGROUND Optimal extent of surgical resection (EOR) of high-grade gliomas (HGGs) remains uncertain in the elderly given the unclear benefits and potentially higher rates of mortality and morbidity… Expand
Personalizing the treatment of pediatric medulloblastoma: Polo-like kinase 1 as a molecular target in high-risk children.
Medulloblastoma is the most common malignant brain tumor in children. This disease is heterogeneous and is composed of four subtypes of medulloblastoma [WNT, Sonic Hedgehog (SHH), Group 3, and Group… Expand
YB-1 bridges neural stem cells and brain tumor-initiating cells via its roles in differentiation and cell growth.
The Y-box binding protein 1 (YB-1) is upregulated in many human malignancies including glioblastoma (GBM). It is also essential for normal brain development, suggesting that YB-1 is part of a neural… Expand