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Naphthalene sulfonate polymers with CD4-blocking and anti-human immunodeficiency virus type 1 activities.
PIC 024-4 and PRO 2000 are naphthalene sulfonate polymers that bind to CD4 with nanomolar affinity and block binding of gp120. Both have activity against human immunodeficiency virus type 1 in H9Expand
Chemical modifications of natural triterpenes - glycyrrhetinic and boswellic acids: evaluation of their biological activity.
Synthetic analogues of naturally occurring triterpenoids; glycyrrhetinic acid, arjunolic acid and boswellic acids, by modification of A-ring with a cyano- and enone- functionalities, have beenExpand
Bioactive metabolites from an endophytic Cryptosporiopsis sp. inhabiting Clidemia hirta.
An endophytic Cryptosporiopsis sp. was isolated from Clidemia hirta and analyzed for its secondary metabolites that lead to the isolation of three bioactive molecules. The compounds were purifiedExpand
Novel Benzimidazole Analogs as Inhibitors of EGFR Tyrosine Kinase
A series of new benzimidazole congeners were synthesized, and their structures were elucidated on the basis of elemental analyses and spectral studies (1H NMR, FT‐IR and EI‐MS). PreliminaryExpand
C-Reactive Protein-Bound Enzymatically Modified Low-Density Lipoprotein Does Not Transform Macrophages into Foam Cells1
The formation of low-density lipoprotein (LDL) cholesterol-loaded macrophage foam cells contributes to the development of atherosclerosis. C-reactive protein (CRP) binds to atherogenic forms of LDL,Expand
Anti-invasive activity of alkaloids and polyphenolics in vitro.
Invasiveness, the ability of certain tumour cells to migrate beyond their natural tissue boundaries, often leads to metastasis, and usually determines the fatal outcome of cancer. The need forExpand
Synthesis, characterization and in vitro anti-invasive activity screening of polyphenolic and heterocyclic compounds.
Invasion is the hallmark of malignant tumors, and is responsible for the bad prognosis of the untreated cancer patients. The search for anti-invasive treatments led us to screen compounds ofExpand
Treponemycin, a nitrile antibiotic active against Treponema hyodysenteriae.
Two strains of Streptomyces sp. (isolates 275 and 124) were isolated from soil samples collected from the fields around Lewiston, Idaho. Based on their cellular morphology and physiology, the twoExpand
Production, purification, and characterization of chandramycin, a polypeptide antibiotic from Streptomyces lydicus.
A plant pathogenic actinomycete identified as Streptomyces lydicus was isolated from the deep-pitted scab lesions of potato tubers. This strain produces a new polypeptide antibiotic namedExpand
Engineered C-reactive protein with improved protective action against pneumococcal infection
The anti-pneumococcal function of native C-reactive protein (CRP) involves the binding of CRP to phosphocholine molecules present on Streptococcus pneumoniae and subsequent activation of theExpand