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Antibody structure, instability, and formulation.
TLDR
The structure and function of antibodies and the mechanisms of physical and chemical instabilities are reviewed and various aspects of formulation development have been examined to identify the critical attributes for the stabilization of antibodies.
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Cuprous Oxidase Activity of CueO from Escherichia coli
TLDR
CueO from Escherichia coli has a robust cuprous oxidase activity, severalfold higher than any homologue, and data suggest that a functional role for CueO in protecting against copper toxicity in vivo includes the removal of Cu(I).
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Tillage and residue management effects on soil aggregation, organic carbon dynamics and yield attribute in rice–wheat cropping system under reclaimed sodic soil
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Potential aggregation prone regions in biotherapeutics
TLDR
This analysis identifies the opportunity and tools for simultaneous optimization of the therapeutic protein sequence for potency and specificity while reducing vulnerability towards aggregation.
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Direct and residual effect of sewage sludge on yield, heavy metals content and soil fertility under rice–wheat system
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An industry perspective on the monitoring of subvisible particles as a quality attribute for protein therapeutics.
TLDR
It is emphasized that the link between aggregation and clinical immunogenicity has not been unequivocally established; and that such particles are present in marketed products which remain safe and efficacious despite the lack of monitoring.
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Impact of product-related factors on immunogenicity of biotherapeutics.
  • S. Singh
  • Biology
    Journal of pharmaceutical sciences
  • 1 February 2011
TLDR
A critical examination of the available data shows that clear unequivocal evidence for the impact of these latter factors on clinical immunogenicity is lacking, and no report could be found that clearly deconvolutes the clinical impact of the product attributes on patient susceptibility.
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Crystal Structures of Multicopper Oxidase CueO Bound to Copper(I) and Silver(I)
TLDR
A role for the methionine-rich insert of CueO in the binding and oxidation of Cu(I) is demonstrated and the interplay among cue and cus systems in copper and silver homeostasis is highlighted.
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Concentration and stock of carbon in the soils affected by land uses and climates in the western Himalaya, India
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Combining ability and heterobeltiosis for yield and yield-contributing traits in Indian mustard (Brassica juncea)
TLDR
Parents used in generating these hybrids are suitable candidates for their conversion to cytoplasmic male sterile and/or restorer lines for the commercial exploitation of heterosis.
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