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Trough concentrations of infliximab guide dosing for patients with inflammatory bowel disease.
After dose optimization, continued concentration-based dosing of infliximab was not superior to clinically based dosing for achieving remission after 1 year, but was associated with fewer flares during the course of treatment.
The burden of endometriosis: costs and quality of life of women with endometriosis and treated in referral centres.
The economic burden associated with endometriosis treated in referral centres is high and is similar to other chronic diseases (diabetes, Crohn's disease, rheumatoid arthritis). It arises predominantly from productivity loss, and is predicted by decreased quality of life.
The significant effect of endometriosis on physical, mental and social wellbeing: results from an international cross-sectional survey.
- A. D. de Graaff, T. D’Hooghe, G. Dunselman, C. Dirksen, L. Hummelshoj, S. Simoens
- MedicineHuman reproduction
- 1 October 2013
Quality of life was decreased in all eight dimensions of the SF-36v2 compared with norm-based scores from a general US population and Multivariate regression analysis showed that number of co-morbidities, chronic pain and dyspareunia had an independent negative effect on both the physical and mental component of the Short Form 36 version 2.
Endometriosis: cost estimates and methodological perspective.
There is a need for more and better-designed studies that carry out longitudinal analyses of patients until the cessation of their symptoms or that model the chronic nature of endometriosis, which is considerably higher than those related to Crohn's disease or to migraine.
Tackling Nurse Shortages in OECD Countries
In order to resolve nurse shortages, the paper compares and evaluates policy levers that decision makers can use to increase flows of nurses into the workforce, reduce flows out of the workforce and improve nurse retention rates.
Paying for the Orphan Drug System: break or bend? Is it time for a new evaluation system for payers in Europe to take account of new rare disease treatments?
- Wills Hughes-Wilson, Ana Palma, A. Schuurman, S. Simoens
- Medicine, Political ScienceOrphanet Journal of Rare Diseases
- 26 September 2012
The authors propose the development of a new assessment system based on several evaluation criteria, which would serve as a tool for Member State governments to evaluate each new orphan drug at the time of pricing and reimbursement.
Impact, regulation and health policy implications of physician migration in OECD countries
- Mélanie Bourassa Forcier, S. Simoens, A. Giuffrida
- Medicine, Political ScienceHuman resources for health
- 16 July 2004
There is a need to create a global framework that enforces physician migration policies that confer benefits on home and host countries and discusses international regulation and policy approaches governing physician migration.
The Supply of Physician Services in OECD Countries
There are signs that a higher density of physicians is found in countries which have left the supply of physicians mainly to the market whereas lower density is finding in countries who have planned the intake to medical schools centrally over many years.
Job Satisfaction and Quitting Intentions: A Structural Model of British General Practitioners
A structural model of job satisfaction and quitting intentions is estimated using data from a survey of general practitioners in the UK. Previous research has used reduced form models, making the…
Economic burden of inadequate management of allergic diseases in the European Union: a GA2LEN review
- T. Zuberbier, J. Lötvall, S. Simoens, S. Subramanian, M. Church
- Medicine, Political ScienceAllergy
- 1 October 2014
In the European Union, between 44 and 76 million individuals of the 217 million EU employees suffer from allergic disease of the airways or the skin, with major socio‐economic consequences such as absence from work (absenteeism), particularly reduced productivity at work (presenteeism).