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Paclitaxel-loaded PLGA nanoparticles: preparation, physicochemical characterization and in vitro anti-tumoral activity.
The main objective of this study was to develop a polymeric drug delivery system for paclitaxel, intended to be intravenously administered, capable of improving the therapeutic index of the drug andExpand
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On the formulation of pH-sensitive liposomes with long circulation times.
Strategies used to enhance liposome-mediated drug delivery in vivo include the enhancement of stability and circulation time in the bloodstream, targeting to specific tissues or cells, andExpand
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Oral films: Current status and future perspectives: I - Galenical development and quality attributes.
Polymers are the most common excipients used in pharmaceutical dosage forms, and often new applications and innovative polymers appear aiming to overcome unmet needs in the drug formulation field. Expand
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On the mechanisms of internalization and intracellular delivery mediated by pH-sensitive liposomes.
We investigated the molecular mechanisms by which pH-sensitive liposomes surpass the cytoplasmic and endosomal membranes to deliver their aqueous contents into the cytoplasm. Various liposomeExpand
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Bridging cancer biology and the patients' needs with nanotechnology-based approaches.
Cancer remains as stressful condition and a leading cause of death in the western world. Actual cornerstone treatments of cancer disease rest as an elusive alternative, offering limited efficacy withExpand
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Tf-lipoplexes for neuronal siRNA delivery: a promising system to mediate gene silencing in the CNS.
Although RNAi-based gene silencing holds a great potential for treatment of neurological disorders, its application to the CNS has been restricted by low levels of tissue distribution and cellularExpand
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Mucoadhesive oral films: The potential for unmet needs.
Oral drug delivery is the most common route of drug administration. Nevertheless, there are some important limitations that reinforce the need for developing new drug delivery systems. MucoadhesiveExpand
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Challenging the future of siRNA therapeutics against cancer: the crucial role of nanotechnology
The identification of numerous deregulated signaling pathways on cancer cells and supportive stromal cells has revealed several molecular targets whose downregulation can elicit significant benefitsExpand
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Cationic liposomes as gene transfer vectors: barriers to successful application in gene therapy.
Despite extensive research in the last decade on the use of cationic liposomes as gene transfer vectors and the development of elegant strategies to enhance their biological activity, these systemsExpand
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