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Identification of the C3bi receptor of human monocytes and macrophages by using monoclonal antibodies.
We have obtained four monoclonal antibodies, IB4, OKM1, OKM9, and OKM10, all directed against the C3bi receptor of human monocytes and macrophages (M phi). Two criteria were used to determine theExpand
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CD36, a class B scavenger receptor, is expressed on microglia in Alzheimer's disease brains and can mediate production of reactive oxygen species in response to beta-amyloid fibrils.
A pathological hallmark of Alzheimer's disease is the senile plaque, composed of beta-amyloid fibrils, microglia, astrocytes, and dystrophic neurites. We reported previously that class A scavengerExpand
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Adult mouse astrocytes degrade amyloid-beta in vitro and in situ.
Alzheimer disease (AD) is a progressive neurodegenerative disorder characterized by excessive deposition of amyloid-beta (Abeta) peptides in the brain. One of the earliest neuropathological changesExpand
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ATP4- permeabilizes the plasma membrane of mouse macrophages to fluorescent dyes.
Extracellular ATP induces cation fluxes in thioglycolate-elicited mouse peritoneal macrophages and the J774 macrophage cell line apparently due to ligation of a plasma membrane receptor for ATP4-. WeExpand
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Endothelial cell cytosolic free calcium regulates neutrophil migration across monolayers of endothelial cells
Polymorphonuclear leukocytes (PMN) traverse an endothelial cell (EC) barrier by crawling between neighboring EC. Whether EC regulate the integrity of their intercellular adhesive and junctionalExpand
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  • Open Access
Legionnaires' disease bacterium (Legionella pneumophila) multiples intracellularly in human monocytes.
We have studied the interaction between virulent egg yolk-grown Legionella pneumophila Philadelphia 1 and human blood monocytes in vitro. The leukocytes were cultured in antibiotic-free tissueExpand
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  • Open Access
Complement receptor type three (CD11b/CD18) of human polymorphonuclear leukocytes recognizes fibrinogen.
Human polymorphonuclear leukocytes (PMN) have previously been shown to bind to aggregates of fibrin and to fibrinogen-coated surfaces. During their interactions with fibrinogen-coated surfaces, PMNExpand
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Scavenger receptors in neurobiology and neuropathology: Their role on microglia and other cells of the nervous system
Scavenger receptor class A (SR‐A, CD204), scavenger receptor‐BI (SR‐BI), and CD36 are cell surface proteins that mediate cell adhesion to, and endocytosis of, various native and pathologicallyExpand
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Scavenger receptor-mediated adhesion of microglia to beta-amyloid fibrils.
A pathological hallmark of Alzheimer's disease is the senile plaque, containing beta-amyloid fibrils, microglia and astrocytes. Beta-amyloid fibrils exert a cytotoxic effect on neurons, and stimulateExpand
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Scavenger receptor-mediated adhesion of microglia to β-amyloid fibrils
A PATHOLOGICALhallmark of Alzheimer's disease is the senile plaque, containing β-amyloid fibrils, microglia and astrocytes1. β-amyloid fibrils exert a cytotoxic effect on neurons2, and stimulateExpand
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