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Teprotumumab for the Treatment of Active Thyroid Eye Disease.
Among patients with active thyroid eye disease, teprotumumab resulted in better outcomes with respect to proptosis, Clinical Activity Score, diplopia, and quality of life than placebo; serious adverse events were uncommon.
Dipeptidyl Peptidase IV in Angiotensin-Converting Enzyme Inhibitor–Associated Angioedema
This case-control study tested the hypothesis that dipeptidyl peptidase IV activity and antigen are decreased in sera of patients with a history of angiotensin-converting enzyme inhibitor–associated angioedema, and found that it was true.
Single-dose, subcutaneous recombinant phenylalanine ammonia lyase conjugated with polyethylene glycol in adult patients with phenylketonuria: an open-label, multicentre, phase 1 dose-escalation trial
Functional BSND variants in essential hypertension.
Molecular physiology of renal ClC chloride channels/transporters
- S. Sile, C. Vanoye, A. George
- Biology, ChemistryCurrent opinion in nephrology and hypertension
- 1 September 2006
New insights into fundamental structure–function relationships, mechanisms of ion translocation, cellular regulation, and roles in human disease have increased attention on ClC proteins as important potential therapeutic targets.
Teprotumumab for patients with active thyroid eye disease: a pooled data analysis, subgroup analyses, and off-treatment follow-up results from two randomised, double-masked, placebo-controlled,…
A likelihood ratio test of population Hardy‐Weinberg equilibrium for case‐control studies
A unified framework enables us to infer the disease‐genotype association when a detected DHWE needs to be part of the model after causes for the DHWE are explored.
CLCNKB-T481S and essential hypertension in a Ghanaian population
It is concluded that CLCNKB-T481S is associated with essential hypertension in males within the Ghanaian population; however, further studies are needed to understand its sex and ethnic segregation as well as to identify cellular factors that account for the divergent functional expression of ClC-Kb-T482S plus barttin in Xenopus oocytes and mammalian cells.
Acute renal failure secondary to spontaneous acute tumor lysis syndrome in myelofibrosis.
This case represents a rare instance of acute renal failure related to the occurrence of acute uric acid nephropathy associated with myelofibrosis and emphasizes the importance of early recognition and aggressive management, which can lead to recovery of renal function.