• Publications
  • Influence
Spectrophotometric assay for D-(-)-lactate in plasma.
Abstract The optimal conditions of pH and temperature for quantitative measurement of d -(−)-lactate (not the l -(+)-lactate of glycolysis) were determined. The procedure used a glycine-hydrazineExpand
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Bacteria lacking a multidrug pump: a sensitive tool for drug discovery.
Microorganisms express multidrug resistance pumps (MDRs) that can confound antibiotic discovery. We propose the use of mutants deficient in MDRs to overcome this problem. Sensitivity to quinolonesExpand
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Human monoclonal antibody HA-1A binds to endotoxin via an epitope in the lipid A domain of lipopolysaccharide.
HA-1A, a human IgM mAb, has been shown to significantly reduce mortality in septic patients with Gram-negative bacteremia, especially those with septic shock, in a controlled clinical trial. ToExpand
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Methylglyoxal production in human blood.
The research of Szent-Györgyi and others has suggested that the three-carbon ketoaldehyde methylglyoxal has a potential role in the control of cell growth. Its metabolism to D-lactate (not theExpand
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Service creation for next-generation networks
This paper describes a framework for service creation that can be applied to converged next-generation networks. Expand
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Network-supported applications
  • S. Siegel
  • Computer Science
  • Bell Labs Technical Journal
  • 14 August 2002
This paper proposes a framework for planning, building, integrating, and growing network support for today's networked applications and those of the future. Expand
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The proteolytic enzymes of the K-1 strain of Streptomyces griseus obtained from a commercial preparation (Pronase). I. Purification of four serine endopeptidases.
Abstract The commercial protease mixture, Pronase, which is obtained from the K-1 strain of Streptomyces griseus, contains many exo- and endopeptidases. Among the latter enzymes are several which areExpand
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The role of nucleoside triphosphate pyrophosphohydrolase in in vitro nucleoside triphosphate-dependent matrix vesicle calcification.
Nucleoside triphosphate pyrophosphohydrolase (EC activity is associated with matrix vesicles purified from collagenase digests of fetal calf epiphyseal cartilage. This enzyme hydrolyzesExpand
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The proteolytic enzymes of the K-1 strain of Streptomyces griseus obtained from a commercial preparation (Pronase). II. The activity of a serine enzyme in 6 M guanidinium chloride.
Abstract A homogeneous serine protease, homologous with bovine chymotrypsin, purified from a commercial preparation (Pronase) of the K-1 strain of Streptomyces griseus demonstrated marked stabilityExpand
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Matrix vesicle enzymes in human osteoarthritis
The enzymatic activities and in vitro calcification properties of matrix vesicle fractions isolated from normal and osteoarthritic (OA) human articular cartilage were compared to determine theExpand
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