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Heterogeneity within the ventricular wall. Electrophysiology and pharmacology of epicardial, endocardial, and M cells.
In spite of important advances in cardiology in recent years, pharmacological control of cardiac arrhythmias in the clinic remains an experiment conducted on a patient-by-patient basis using a trialExpand
Clinical relevance of cardiac arrhythmias generated by afterdepolarizations. Role of M cells in the generation of U waves, triggered activity and torsade de pointes.
A brief review examines the implications of some of new findings within the scope of what is already known about early and delayed afterdepolarizations and triggered activity and discusses the possible relevance of these mechanisms to clinical arrhythmias. Expand
A subpopulation of cells with unique electrophysiological properties in the deep subepicardium of the canine ventricle. The M cell.
Evidence is presented for the existence of a unique subpopulation of cells in the deep subepicardial layers of the canine left and right ventricles with electrophysiological features intermediate between those of conducting and myocardial cells that may facilitate conduction in epicardium and are likely to influence or mediate the manifestation of electrocardiographic J waves, T waves, U waves, and long QT intervals. Expand
Electrophysiologic basis for the antiarrhythmic actions of ranolazine.
Short- and long-term safety of ranolazine has been demonstrated in the clinic, even in patients with structural heart disease, and the drug may be effective and safe in suppressing AF when used as a pill-in-the pocket approach, warranting further study. Expand
Does Tpeak-Tend provide an index of transmural dispersion of repolarization?
Tpeak-Tend is more valuable than QTc and QT dispersion as a predictor of TdP in patients with acquired LQTS and changes in this parameter are thought to be capable of reflecting changes in spatial dispersion of repolarization, particularly TDR, and thus may be prognostic of arrhythmic risk under a variety of conditions. Expand
Cellular basis for QT dispersion.
The data indicate that the interval delimited by the peak and the end of the T wave represents an accurate measure of regional dispersion of repolarization across the ventricular wall and as such may be a valuable index for assessment of arrhythmic risk. Expand
Chronic Amiodarone Reduces Transmural Dispersion of Repolarization in the Canine Heart
The present study was designed to examine the effects of chronic amiodarone in epicardial, endocardial, and M cells of the canine left ventricle. Expand
Effects of Sodium Channel Block with Mexiletine to Reverse Action Potential Prolongation in In Vitro Models of the Long QT Syndrome
Examination of the effects of mexiletine is examined in isolated canine ventricular epicardial, endocardial, and M region tissues under conditions that mimic the SCN5A and HERG gene defects to test the possibility of gene‐specific therapy for the two distinct forms of the congenital LQTS. Expand
Genetic and biophysical basis for bupivacaine-induced ST segment elevation and VT/VF. Anesthesia unmasked Brugada syndrome.
Findings indicate that bupivacaine may induce the electrocardiographic and arrhythmic manifestations of the Brugada syndrome in silent carriers of SCN5A mutations, which has important implications in the management of patients who develop ST segment elevation when under the influence of anesthetics such as bupvacaine. Expand
Synergistic Electrophysiologic and Antiarrhythmic Effects of the Combination of Ranolazine and Chronic Amiodarone in Canine Atria
The combination of chronic amiodarone and acute ranolazine produces a synergistic use-dependent depression of INa-dependent parameters in isolated canine atria, leading to a potent effect of the drug combination to prevent the induction of atrial fibrillation. Expand