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Zelda Potentiates Morphogen Activity by Increasing Chromatin Accessibility
Zygotic genome activation (ZGA) is a major genome programming event whereby the cells of the embryo begin to adopt specified fates. Experiments in Drosophila and zebrafish have revealed that ZGAExpand
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Bistability and Oscillations in the Huang-Ferrell Model of MAPK Signaling
Physicochemical models of signaling pathways are characterized by high levels of structural and parametric uncertainty, reflecting both incomplete knowledge about signal transduction and theExpand
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Role of boundary conditions in an experimental model of epithelial wound healing.
Coordinated cell movements in epithelial layers are essential for proper tissue morphogenesis and homeostasis, but our understanding of the mechanisms that coordinate the behavior of multiple cellsExpand
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Vertex models of epithelial morphogenesis.
The dynamic behavior of epithelial cell sheets plays a central role during numerous developmental processes. Genetic and imaging studies of epithelial morphogenesis in a wide range of organisms haveExpand
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The Capicua repressor – a general sensor of RTK signaling in development and disease
Receptor tyrosine kinase (RTK) signaling pathways control multiple cellular decisions in metazoans, often by regulating the expression of downstream genes. In Drosophila melanogaster and otherExpand
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Dynamics of the Dorsal morphogen gradient
The dorsoventral (DV) patterning of the Drosophila embryo depends on the nuclear localization gradient of Dorsal (Dl), a protein related to the mammalian NF-κB transcription factors. CurrentExpand
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Computational modeling of the EGF-receptor system: a paradigm for systems biology.
Computational models have rarely been used as tools by biologists but, when models provide experimentally testable predictions, they can be extremely useful. The epidermal growth factor receptorExpand
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Nuclear Trapping Shapes the Terminal Gradient in the Drosophila Embryo
Patterning of the terminal regions of the Drosophila embryo relies on the gradient of phosphorylated ERK/MAPK (dpERK), which is controlled by the localized activation of the Torso receptor tyrosineExpand
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A combinatorial code for pattern formation in Drosophila oogenesis.
Two-dimensional patterning of the follicular epithelium in Drosophila oogenesis is required for the formation of three-dimensional eggshell structures. Our analysis of a large number of publishedExpand
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Three-dimensional epithelial morphogenesis in the developing Drosophila egg.
Morphogenesis of the respiratory appendages on eggshells of Drosophila species provides a powerful experimental system for studying how cell sheets give rise to complex three-dimensional structures.Expand
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