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Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow
We have resolved B220+ IgM- B-lineage cells in mouse bone marrow into four fractions based on differential cell surface expression of determinants recognized by S7 (leukosialin, CD43), BP-1, and 30F1Expand
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Resolution of Three Nonproliferative Immature Splenic B Cell Subsets Reveals Multiple Selection Points During Peripheral B Cell Maturation1
Although immature/transitional peripheral B cells may remain susceptible to selection pressures before full maturation, the nature and timing of these selection events remain unclear. We show thatExpand
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The Immunological Genome Project: networks of gene expression in immune cells
The Immunological Genome Project combines immunology and computational biology laboratories in an effort to establish a complete 'road map' of gene-expression and regulatory networks in all immuneExpand
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Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression
The TCL1 gene at 14q32.1 is involved in chromosomal translocations and inversions in mature T cell leukemias. These leukemias are classified either as T prolymphocytic leukemias, which occur veryExpand
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Deciphering the transcriptional network of the dendritic cell lineage - eScholarship
Although much progress has been made in the understanding of the ontogeny and function of dendritic cells (DCs), the transcriptional regulation of the lineage commitment and functional specializationExpand
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Positive selection of natural autoreactive B cells.
Lymphocyte development is critically influenced by self-antigens. T cells are subject to both positive and negative selection, depending on their degree of self-reactivity. Although B cells areExpand
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Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice.
We have examined the regulatory role of the individual components of the immunoglobulin antigen receptor in B-cell development by transgenic complementation of Rag-1 deficient (Rag-1-) mice.Expand
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Lineage specification and plasticity in CD19− early B cell precursors
We describe here three CD19− B cell precursor populations in mouse bone marrow identified using 12-color flow cytometry. Cell transfer experiments indicate lineage potentials consistent withExpand
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Both E12 and E47 allow commitment to the B cell lineage.
The E2A gene products, E12 and E47, are required for proper B cell development. Mice lacking the E2A gene products generate only a very small number of B220+ cells, which lack immunoglobulin DJ(H)Expand
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Basal Immunoglobulin Signaling Actively Maintains Developmental Stage in Immature B Cells
In developing B lymphocytes, a successful V(D)J heavy chain (HC) immunoglobulin (Ig) rearrangement establishes HC allelic exclusion and signals pro-B cells to advance in development to the pre-BExpand
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