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Macrophage inhibitory cytokine-1 induces the invasiveness of gastric cancer cells by up-regulating the urokinase-type plasminogen activator system.
The results indicate that MIC-1 may contribute to the malignant progression of gastric cancer cells by inducing tumor cell invasion through the up-regulation of the uPA activation system via extracellular signal-regulated kinase-1/2-dependent pathway. Expand
Activation of protease-activated receptor1 mediates induction of matrix metalloproteinase-9 by thrombin in rat primary astrocytes
The results suggest that the activation of PAR1 mediates thrombin-induced MMP-9 expression through the regulation of Erk1/2. Expand
ATP induced microglial cell migration through non-transcriptional activation of matrix metalloproteinase-9
The results from the present investigation may provide further insights into the regulation of the activity of MMP-9 during microglial migration, which may play essential role in theregulation of inflammatory responses in pathological situations such as neurodegenerative disorders. Expand
Plasminogen Activator System Urokinase-typeof Gastric Cancer Cells by Up-Regulating the Macrophage Inhibitory Cytokine-1 Induces the Invasiveness
In our search for genes associated with gastric cancer progression, we identified macrophage inhibitory cytokine-1 (MIC-1), a member of the transforming growth factor superfamily, as an overexpressed… Expand
Enhanced angiogenesis mediated by vascular endothelial growth factor plasmid-loaded thermo-responsive amphiphilic polymer in a rat myocardial infarction model.
- J. Kwon, I. Park, +13 authors Y. Ahn
- Biology, Medicine
- Journal of controlled release : official journal…
- 1 September 2009
Thermo-responsive hydrogel-mediated gene transfer in the heart improved gene expression up to 4 fold, compared with naked plasmid, and displayed 2 bi-modal expression profiles with peaks at 2 days and around 25 days after local injection. Expand
Heat shock factor regulates VDUP1 gene expression.
- Kun-Yong Kim, S. Shin, J. K. Kim, S. Paik, Young Yang, I. Choi
- Biology, Medicine
- Biochemical and biophysical research…
- 5 March 2004
It is implied that HSF is an important transcription factor involved in up-regulation of VDUP1 expression by stresses such as high density and serum deprivation cultures. Expand
Urokinase-Type Plasminogen Activator Induces BV-2 Microglial Cell Migration Through Activation of Matrix Metalloproteinase-9
The results suggest that uPA plays a critical role in BV-2 microglial cell migration by activating pro-MMP-9, in part by its direct action on M MP-9 and also by the activation of plasminogen/plasmin cascade. Expand
Dexamethasone reverses TGF‐β‐mediated inhibition of primary rat preadipocyte differentiation
- S. Shin, Kun-Yong Kim, J. K. Kim, S. Yoon, I. Choi, Young Yang
- Chemistry, Medicine
- FEBS letters
- 22 May 2003
Results indicate that dexamethasone reverses the TGF‐β‐mediated suppression of adipocyte differentiation by regulating the expression of C/EBPα and PPARγ, which is dependent on the cellular context. Expand
Transcriptional regulation of the mouse calbindin-D9k gene by the ovarian sex hormone.
In the uterus of oophorectomized mice, the calbindin-D9k gene was up-regulated by progesterone, but not by estrogen, which suggests that the mouse uterine calbind in D9K gene is expressed under the control of a PRE. Expand
Inhibitory Effects of Coptis japonica Alkaloids on the LPS-Induced Activation of BV2 Microglial Cells
The anti-inflammatory effect of palmatine in LPS-stimulated microglia may suggest the potential use of the alkaloids in the modulation of neuroinflammatory responses, which might be important in the pathophysiological events of several neurological diseases including Alzheimer`s disease (AD), multiple sclerosis (MS), Parkinson's disease (PD) and stroke. Expand