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Mountain grown ginseng induces apoptosis in HL-60 cells and its mechanism have little relation with TNF-alpha production.
It is found that MGG is a potent inducer of apoptosis, but it has less effect on human peripheral blood mononuclear cells, and these abilities could be used clinically for the treatment of cancer. Expand
The Korean traditional medicine Gyeongshingangjeehwan inhibits obesity through the regulation of leptin and PPARalpha action in OLETF rats.
The results suggest that GGEx may effectively prevent obesity and hypertriglyceridemia in part through the inhibition of feeding and the activation of hepatic PPARalpha. Expand
Korean red ginseng (Panax ginseng) inhibits obesity and improves lipid metabolism in high fat diet-fed castrated mice.
  • S. Shin, M. Yoon
  • Medicine, Biology
  • Journal of ethnopharmacology
  • 10 January 2018
It is demonstrated that ginseng can inhibit obesity and dyslipidemia in HFD-fed castrated mice, possibly by inhibiting adipogenic gene expression, and indicated thatginseng may act like testosterone to inhibit adipogenesis, suggesting that gINSeng may be able to prevent obesity, hyperlipidia, and hepatic steatosis in men with testosterone deficiency. Expand
Effects of Korean red ginseng (Panax ginseng) on obesity and adipose inflammation in ovariectomized mice.
Ginseng inhibited ovariectomy-induced obesity, adiposity, and adipocyte hypertrophy by modulating angiogenesis and MMP activity, suggesting that ginseng may be a promising drug for the prevention and treatment of obesity and related disorders in obese postmenopausal women. Expand
The herbal composition GGEx18 from Laminaria japonica, Rheum palmatum, and Ephedra sinica inhibits visceral obesity and insulin resistance by upregulating visceral adipose genes involved in fatty
The results suggest that GGEx18 may treat visceral obesity and visceral obesity-related insulin resistance by upregulating the visceral adipose expression of fatty acid oxidative genes. Expand
The Korean traditional medicine gyeongshingangjeehwan inhibits adipocyte hypertrophy and visceral adipose tissue accumulation by activating PPARalpha actions in rat white adipose tissues.
Results suggest that GGEx promotes the reductions in visceral fat mass and adipocyte size in obese animals, and that this event may be mediated by adipose PPARalpha activation. Expand
Reduction of Adipose Tissue Mass by the Angiogenesis Inhibitor ALS-L1023 from Melissa officinalis
Results suggest that ALS, which has antiangiogenic and MMP inhibitory activities, reduces adipose tissue mass in nutritionally obese mice, demonstrating that adipOSE tissue growth can be regulated by angiogenesis inhibitors. Expand
Effect of Gangjihwan on hepatic steatosis and inflammation in high fat diet-fed mice.
Results indicate that DF inhibits obesity and obesity-induced severe hepatic steatosis and inflammation without any adverse effects and suggest that DF is a safe and efficient anti-obesity and anti-nonalcoholic steatohepatosis drug. Expand
The herbal composition GGEx18 from Laminaria japonica, Rheum palmatum, and Ephedra sinica inhibits high-fat diet-induced hepatic steatosis via hepatic PPARα activation
  • S. Shin, M. Yoon
  • Biology, Medicine
  • Pharmaceutical biology
  • 7 September 2012
The results suggest that Gyeongshingangjeehwan 18 prevents hepatic steatosis and hyperlipidemia in high-fat diet-induced obese mice, and this process may be mediated through PPARα activation in the liver. Expand
The polyherbal drug GGEx18 from Laminaria japonica, Rheum palmatum, and Ephedra sinica inhibits hepatic steatosis and fibroinflammtion in high-fat diet-induced obese mice.
The results indicate that GGEx18 attenuates visceral obesity and NAFLD, in part by altering the expression of genes involved in hepatic steatosis and fibroinflammation in HFD-induced obese mice. Expand