• Publications
  • Influence
Genesis and expansion of metazoan transcription factor gene classes.
Transcription factor orthologues present in sponge, cnidarian, and bilaterian genomes may represent part of the core metazoan regulatory network underlying the origin of animal development and multicellularity. Expand
Pitx homeobox genes in Ciona and amphioxus show left–right asymmetry is a conserved chordate character and define the ascidian adenohypophysis
Describing Pitx genes from Branchiostoma floridae and Ciona intestinalis shows that asymmetrical Pitx gene expression, and by inference directional asymmetry, evolved before the radiation of living chordates and should be considered a chordate character. Expand
Molecular evidence from Ciona intestinalis for the evolutionary origin of vertebrate sensory placodes.
Data are interpreted as support for the hypothesis that sensory placodes did not arise de novo in vertebrates, but evolved from pre-existing specialised areas of ectoderm that contributed to sensory organs in the common ancestor of vertebrates and tunicates. Expand
A genomewide survey of developmentally relevant genes in Ciona intestinalis
Almost complete sets of genes for Fox, ETS-domain transcription factors, nuclear receptors, andNFκB as well as other factors regulating NFκB activity are described, with their phylogenetic nature. Expand
Vertebrate innovations.
  • S. Shimeld, P. Holland
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 25 April 2000
Comparative molecular and developmental data give new insights into the evolutionary origins of vertebrate characteristics and the complexity of the vertebrate body. Expand
Phylogenetic relationships of the Fox (Forkhead) gene family in the Bilateria.
It is suggested that the common ancestor of protostomes and deuterostomes had a minimum complement of 14 Fox genes, and four subclasses (FoxJ, L, N and Q) could be further subdivided to reflect their relationships to invertebrate genes. Expand
The evolution of the hedgehog gene family in chordates: insights from amphioxus hedgehog
  • S. Shimeld
  • Biology, Medicine
  • Development Genes and Evolution
  • 1999
Data show that notochord, floor plate and possibly left/right asymmetric expression are ancestral sites of hedgehog expression in vertebrates and amphioxus, suggesting that Desert-type and Indian-type hedgehog genes may have freed from selective constraint and taken on new roles in different vertebrate taxa. Expand
The development of the larval nervous system, musculature and ciliary bands of Pomatoceros lamarckii (Annelida): heterochrony in polychaetes
A comparison between polychaetes shows variability in the timing (heterochrony) of development of body wall muscles and elements of the nervous system, one route for evolution of different life history strategies, such as adaptations to feeding requirements. Expand
Evolution of bilaterian central nervous systems: a single origin?
The bulk of the evidence indicates that a CNS evolved just once – in the ancestral bilaterian; however, an alternative view proposes that the chordate CNS evolved from the ectodermal nerve net of a hemichordate-like ancestral deuterostome, implying independent evolution of the CNS in chordates and protostomes. Expand
The Fox genes of Branchiostoma floridae
The Fox genes are united by encoding a fork head domain, a deoxyribonucleic acid (DNA)-binding domain of the winged-helix type that marks these genes as encoding transcription factors, and it is concluded B. floridae has maintained a high level of Fox gene diversity. Expand