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Electromechanical effects of okadaic acid isolated from black sponge in guinea‐pig ventricular muscles.
It is suggested that okadaic acid has a positive inotropic effect on the heart, probably due to the enhancement of slow Ca2+ and/or Na+ inward current through the cell membrane.
THE POTENT DEPOLARIZING ACTION OF PALYTOXIN ISOLATED FROM Palythoa Tubercurosa ON THE ISOLATED SPINAL CORD OF THE FROG
It is suggested that PTX may interfere with the stabilizing action of Ca2+ on the neuronal membrane, consequently facilitating Na+ permeability and the primary amine in the PTX molecule may be important for its pharmacological action.
Vasorelaxing action of melatonin in rabbit basilar artery.
The contractile mechanism of sodium metavanadate in isolated rat aortae.
In rat aortae, NaVO3 increased the levels of inositol monophosphate (IP) and prostaglandin F2alpha (PGF2alpha) and inhibited the IP increase and the PGF2alpha increase, suggesting that the response to Na VO3 in rat aortsae may be mainly the result of the increased phosphoinositide metabolism.
Inhibitory effect of sodium nitroprusside on the relaxing action of isoproterenol in isolated rat urinary bladder.
Electrical property of cardiac cell membrane of spontaneously hypertensive rat.
The inhibitory effects of iberiotoxin and 4-aminopyridine on the relaxation induced by beta 1- and beta 2-adrenoceptor activation in rat aortic rings.
Results suggest that, in rat aortic rings, KCa channels are involved in the relaxation induced by isoprenaline, and are mainly activated by beta 2-adrenoceptors through cyclic AMP-dependent pathways.
Antagonizing action of chlorpromazine, dibenamine, and phenoxybenzamine on potassium-induced contraction.
It was found that the three agents blocking the potassium-induced contraction inhibited calcium-45 uptake during these contractions; however, they did not inhibit the calcium- 45 uptake of unstimulated muscle.
Effect of Prolonged Cold Storage on the Contractile Response of Strips of Rabbit Aorta to Various Agents
- S. Shibata
- BiologyCirculation research
- 1 February 1969
The results indicate that cold storage, up to 7 days, does not interfere with the activation system related to epinephrine- or norepinephrine-induced contractions, however, such treatment does affect the membrane system involved in potassium-induced contraction.
Adrenergic innervation and cocaine-induced potentiation of adrenergic responses of aortic strips from young and old rabbits.
- S. Shibata, K. Hattori, I. Sakurai, J. Mori, M. Fujiwara
- Biology, MedicineThe Journal of pharmacology and experimental…
- 1 June 1971
The results suggest that adrenergic nerve fibers penetrate into the smooth muscle layer of the rabbit aortae, but that the cocaine-induced potentiation may not be dependent on these adren allergic nerve terminals in the aortic media.