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Conformational dynamics of ligand-dependent alternating access in LeuT
The leucine transporter (LeuT) from Aquifex aeolicus is a bacterial homolog of neurotransmitter/sodium symporters (NSSs) that catalyze reuptake of neurotransmitters at the synapse. Crystal structuresExpand
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Purine biosynthetic pathway genes and methotrexate response in rheumatoid arthritis patients among north Indians
Objective Inter-individual variations to methotrexate (MTX) response among rheumatoid arthritis (RA) patients have been attributed to clinical heterogeneity and genetic variations influencing MTXExpand
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Association of TNF polymorphisms with sarcoidosis, its prognosis and tumour necrosis factor (TNF)‐α levels in Asian Indians
Tumour necrosis factor (TNF)‐α, an important proinflammatory cytokine, has been implicated in the pathogenesis of sarcoidosis, a multi‐systemic granulomatous disorder of unknown aetiology. Here, weExpand
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Conformational cycle and ion-coupling mechanism of the Na+/hydantoin transporter Mhp1
Significance Na+-coupled symporters use the cellular Na+ gradient to power transport of physiologically important molecules across the lipid membrane. However, the mechanism by which binding andExpand
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Interaction of genes from influx-metabolism-efflux pathway and their influence on methotrexate efficacy in rheumatoid arthritis patients among Indians
Objective Methotrexate (MTX) is the drug of choice for rheumatoid arthritis (RA) but is effective only in around 60% of treated patients. Bioavailability of MTX may be a major determinant of responseExpand
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Antimicrobial Peptides and their Pore/Ion Channel Properties in Neutralization of Pathogenic Microbes.
The essence of successful antimicrobial chemotherapy lies in selective toxicity of the agent towards the pathogen. An ideal antimicrobial agent should kill pathogens effectively with little or noExpand
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Melasma: a clinicopathological study of 43 cases.
Melasma is a symmetrical hypermelanosis of the exposed skin characterized by brown macules on the sun-exposed areas of the skin. The present study was carried out on 43 patients to analyze theExpand
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Steroid cell tumor: a rare cause of hirsutism in a female
Summary Ovarian steroid cell tumors are very rare functioning sex-cord stromal tumors. They comprise <0.1% of all ovarian tumors. Previously designated as lipoid cell tumors, one-third of theseExpand
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Light and electron microscopic features of surgically excised left atrial appendage in rheumatic heart disease patients with atrial fibrillation and sinus rhythm.
INTRODUCTION There are few studies comparing the pathology of the remodeled substrate in patients of rheumatic heart disease with atrial fibrillation (AF) and normal sinus rhythm (NSR). METHODS TheExpand
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IGF-Binding Proteins in Type-1 Diabetes Are More Severely Altered in the Presence of Complications
Aims Reduced levels of free and total insulin-like growth factor 1 (IGF-I) have been observed in type-1 diabetes (T1D) patients. The bioavailability of IGF-I from the circulation to the target cellsExpand
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