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The pervasive presence of fluctuating oxygenation in tumors.
- L. I. Cárdenas-Navia, D. Macé, R. A. Richardson, D. Wilson, S. Shan, M. Dewhirst
- Cancer research
- 15 July 2008
Tumor hypoxia is a persistent obstacle for traditional therapies in solid tumors. Strategies for mitigating the effects of hypoxic tumor cells have been developed under the assumption that… Expand
In vivo optical molecular imaging and analysis in mice using dorsal window chamber models applied to hypoxia, vasculature and fluorescent reporters
Optical techniques for functional imaging in mice have a number of key advantages over other common imaging modalities such as magnetic resonance imaging, positron emission tomography or computed… Expand
Inhibition of rat corneal angiogenesis by a nuclease-resistant RNA aptamer specific for angiopoietin-2
- R. White, S. Shan, +4 authors B. Sullenger
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 11 April 2003
Angiopoietin-2 (Ang2) appears to be a naturally occurring antagonist of the endothelial receptor tyrosine kinase Tie2, an important regulator of vascular stability. Destabilization of the endothelium… Expand
Epinephrine-induced activation of LW-mediated sickle cell adhesion and vaso-occlusion in vivo.
Sickle red cell (SS RBC) adhesion is believed to contribute to the process of vaso-occlusion in sickle cell disease (SCD). We previously found that the LW RBC adhesion receptor can be activated by… Expand
Bromelain treatment decreases neutrophil migration to sites of inflammation.
Bromelain, a mixture of proteases derived from pineapple stem, has been reported to have therapeutic benefits in a variety of inflammatory diseases, including murine inflammatory bowel disease. The… Expand
Research on e-Government evaluation model based on the principal component analysis
This study presents, validates and updates an evaluation model with 5 dimensions based on Socio-Technical model and Stakeholder Theory, which captures the multidimensional and interdependent nature of e-Government system. Expand
Observation of incipient tumor angiogenesis that is independent of hypoxia and hypoxia inducible factor-1 activation.
It is well established that hypoxia potently stimulates tumor angiogenesis by activating hypoxia inducible factor-1 (HIF-1)-induced proangiogenic factors, such as vascular endothelial growth factor.… Expand
A novel rodent mammary window of orthotopic breast cancer for intravital microscopy.
Orthotopic and ectopic organ environments differentially influence tumor growth, metastasis, and sensitivity to therapy. In this study we present a novel rodent mammary window of orthotopic breast… Expand
Angiostatin-like activity of a monoclonal antibody to the catalytic subunit of F1F0 ATP synthase.
The antiangiogenic protein angiostatin inhibits ATP synthase on the endothelial cell surface, blocking cellular proliferation. To examine the specificity of this interaction, we generated monoclonal… Expand
An emergency response decision support system framework for application in e-government
An emergency response decision support system (ERDSS) needs to assist decision makers to evaluate emergency plans and select an appropriate one during an emergency by supporting heterogeneous emergency response data sources and providing the access to appropriate emergency rescue knowledge. Expand