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Fungal allergy in asthma–state of the art and research needs
TLDR
Key evidence supporting the role of fungal exposure, sensitisation and infection in asthmatics is set out, what is understood about pathogenesis and natural history is understood and the numerous areas for research studies are identified. Expand
EAACI position statement on asthma exacerbations and severe asthma
TLDR
Current evidence that supports a call for increased awareness of the seriousness of asthma exacerbations and the need for novel treatment strategies in specific forms of severe treatment‐resistant asthma are reviewed. Expand
Interleukin-17 as a recruitment and survival factor for airway macrophages in allergic airway inflammation.
TLDR
It is indicated that endogenous IL-17 mediates the accumulation of macrophages during allergen-induced airway inflammation and is involved in controlling the proteolytic activity of Macrophages and neutrophils in allergenic-inducedAirway inflammation. Expand
Research needs in allergy: an EAACI position paper, in collaboration with EFA
TLDR
The present EAACI Position Paper, in collaboration with EFA, highlights the most important research needs in the field of allergy to serve as key recommendations for future research funding at the national and European levels. Expand
Allergen exposure-induced differences in CD34+ cell phenotype: relationship to eosinophilopoietic responses in different compartments.
TLDR
It is demonstrated in vitro that ability to multiply persists in BALfCD34(+) cells but not CD34(-) cells, likely via autocrine IL-5 release andIL-5-induced up-regulation of IL- 5R alpha, and that the phenotype of airway eosinophils depends on whether these cells have differentiated within BM or airway. Expand
Smoothened agonist augments proliferation and survival of neural cells
TLDR
In vitro experiments demonstrated that SAG in low-nanomolar concentrations induces proliferation of neuronal and glial precursors without affecting the differentiation pattern of newly produced cells and, in contrast to Shh, SAG did not induce neurotoxicity in neuronal cultures. Expand
Regulation of bone marrow and airway CD34+ eosinophils by interleukin-5.
TLDR
The data argue that anti-IL-5 downregulates eosinophilopoiesis within 3 d by action in the bone marrow, by inhibition of the early stages of eos inophil maturation from CD34(+) cells. Expand
Allergen‐induced traffic of bone marrow eosinophils, neutrophils and lymphocytes to airways
TLDR
Allergen exposure induces traffic of not only newly produced eosinophils but also newly produced neutrophils and lymphocytes into the airways and enhanced the number of CD34+ cells in BM and blood after allergen Exposure. Expand
Mucin5B expression by lung alveolar macrophages is increased in long‐term smokers
TLDR
M UC5B is expressed in a subset of lung AMs and long‐term cigarette smoking may increase the level of MUC5B produced by these cells. Expand
Sonic Hedgehog pathway activity in prostate cancer.
TLDR
A significant age-dependent increase in the number of Shh, Gli1,gli3 and FoxA1-positive prostate cells and a decrease in Gli2-positive cells in TRAMP is shown, which supports the hypothesis that the development of prostate cancer and its metastasis is associated with activation of the Shh signaling pathway. Expand
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