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GABAergic System in the Anxiolytic Effect of Proproten: Experimental Study
TLDR
The results suggest that the GABAergic system plays a role in the anxiolytic effect of diazepam, mexidol, and Proproten.
Involvement of the serotoninergic system in the mechanism of action of ultralow dose antibodies to S-100 protein
TLDR
Administration of ultralow-dose antibodies to S-100 protein in combination with serotoninergic agents (ketanserin and 5-hydroxytryptophan) reduced the anxiolytic and antidepressant effects of antibodies.
Sildenafil and a compound stimulating endothelial NO synthase modify sexual incentive motivation and copulatory behavior in male Wistar and Fisher 344 rats.
TLDR
The nitric oxide-guanylyl cyclase pathway seems to be of importance for sexual incentive motivation in animals with a modest baseline level and the different drug effects in the Wistar and Fisher 344 rats can be attributed to baseline differences.
Effects of chronic treatment with the eNOS stimulator Impaza on penis length and sexual behaviors in rats with a high baseline of sexual activity
TLDR
Impaza enhanced intracavernous pressure, as such a pressure increase is the most likely explanation for enhanced penis length at mount, and suggests that Impaza may be the most valuable treatment for erectile dysfunction.
Dose-Dependent Effects and Specificity of Action of Antibodies to Endogenous Regulators in Ultralow Doses
TLDR
The effects of antibodies against interferon-γ, erythropoietin, and tumor necrosis factor-α in ultralow doses on the production of endogenous interferons-γ are studied to illustrate the specificity of action of antibodies to endogenous regulators in ultRALow doses.
Study of antidiabetic activity of a new ultralow-dose antibody preparation on the model of streptozotocin diabetes in rats
TLDR
Antidiabetic activity of a new ultralow-dose preparation of antibodies to insulin receptor β-subunit was revealed on the model of streptozotocin diabetes in rats: treatment with this preparation normalized blood glucose level, restored glucose tolerance in the oral glucose test and body weight gain, and improved animal survival.
[Adamantane derivatives enhancing body's resistance to emergencies].
TLDR
2-(para-chlorobenzoylamine)adamantane (chlodantane) has the processes of a rapid-action adaptogenic agent by enhancing the resistance of animals to various physical and toxically chemical noxious agents.
A Rapid and Sensitive LC-MS/MS Assay for the Quantitation of Bromantane in Human Plasma
The purpose of this study was to develop and validate a high-performance liquid chromatographic–tandem mass spectrometric (LC–MS/MS) method for analysis of the bromantane in human plasma. The analyte
Antibodies to S100 proteins have anxiolytic‐like activity at ultra‐low doses in the adult rat
TLDR
Results indicate the presence of anxiolytic‐like activity for antibodies to S100 proteins over the dose range 5–10 mL kg−1 in the adult rat.
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