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IL-18 in inflammatory and autoimmune disease
TLDR
The role of IL-18 in inflammatory responses with emphasis on autoimmune diseases is focused on and an enzyme, caspase-1, which upon activation cleaves pro-forms of cytokines leading to subsequent release of active IL-1 and IL- 18 is reviewed.
Immunomodulatory Type II Natural Killer T Lymphocytes in Health and Disease
TLDR
Recent progress in the study of type II NKT cells is reviewed, supporting the view that type IINKT cells may be attractive targets for immunotherapy.
PPAR-γ promotes type 2 immune responses in allergy and nematode infection
TLDR
Mice lacking PPAR-γ in T cells failed to effectively differentiate into IL-5– and IL-13–secreting cells and, hence, did not develop TH2 cell–associated pathologies and could not mount protective immune responses to nematode infection.
Combination of KIR 2DL2 and HLA‐C1 (Asn80) confers susceptibility to type 1 diabetes in Latvians
TLDR
The results suggest that a combination KIR2DL2‐ HLA‐C1 plays a critical role in susceptibility or protection in Latvians against type 1 diabetes.
Association of SUMO4 M55V Polymorphism with Autoimmune Diabetes in Latvian Patients
TLDR
SUMO4 M55V is not associated with susceptibility to T1DM and LADA in Latvian, and Latvians exhibit similarity to other Caucasians with respect to association of SUMO4M55V with autoimmune diabetes.
A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage
TLDR
A series of small molecule dihydroorotate dehydrogenase (DHODH) inhibitors are discovered that increase p53 synthesis and reduce tumor growth in synergy with the common mdm2 inhibitor nutlin3.
Neutrophils license iNKT cells to regulate self-reactive mouse B cell responses
TLDR
An accumulation of B cell–helper neutrophils in the spleen that interacted with innate-type invariant natural killer T cells (iNKT cells) to regulate B cell responses was identified and it was found that neutrophil-dependent expression of the death-receptor ligand FasL by iN KT cells was needed to restrict autoantibody production.
Different KIRs Confer Susceptibility and Protection to Adults with Latent Autoimmune Diabetes in Latvian and Asian Indian Populations
TLDR
It is concluded that KIRs are important in conferring susceptibility (or protection) to adult patients with LADA in both the authors' study populations, however the KIR genes (and their HLA‐C ligands) conferting susceptibility or protection in these two populations differ, showing a role of ethnicity in disease susceptibility.
Risk conferred by HLA-DR and DQ for type 1 diabetes in 0-35-year age group in Sweden.
TLDR
The risk conferred by high-risk HLA varies in different regions for a homogenous population in Sweden, highlighting the important role played by the various environmental factors in the precipitation of T1D.
Selective Memory to Apoptotic Cell–Derived Self-Antigens with Implications for Systemic Lupus Erythematosus Development
TLDR
Evidence is provided for a selective self-memory that underlies progression of the response to self-antigens with implications for SLE development therapy.
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