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Initial sequencing and comparative analysis of the mouse genome
The sequence of the mouse genome is a key informational tool for understanding the contents of the human genome and a key experimental tool for biomedical research. Here, we report the results of anExpand
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Genes that distinguish physiological and pathological angiogenesis.
To unravel the normal vasculature transcriptome and determine how it is altered by neighboring malignant cells, we compared gene expression patterns of endothelial cells derived from the bloodExpand
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GPR124 functions as a WNT7-specific coactivator of canonical β-catenin signaling.
G protein-coupled receptor 124 (GPR124) is an orphan receptor in the adhesion family of GPCRs, and previous global or endothelial-specific disruption of Gpr124 in mice led to defective CNSExpand
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GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood–brain barrier
Every organ in the body requires blood vessels for efficient delivery of oxygen and nutrients, but independent vascular beds are highly specialized to meet the individual needs of specific organs.Expand
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  • Open Access
Host-derived tumor endothelial marker 8 promotes the growth of melanoma.
Tumor endothelial marker 8 (TEM8) was initially identified as a gene overexpressed in the vasculature of human tumors and was subsequently identified as an anthrax toxin receptor. To assess theExpand
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COX-2 Inhibition Potentiates Antiangiogenic Cancer Therapy and Prevents Metastasis in Preclinical Models
Inhibition of cyclooxygenase-2 (COX-2) inhibits angiogenesis, suppresses tumor growth, and augments the effects of traditional angiogenesis inhibitors. An Old Drug Knows New Anticancer TricksExpand
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Eradication of Tumors through Simultaneous Ablation of CD276/B7-H3-Positive Tumor Cells and Tumor Vasculature.
Targeting the tumor vasculature with antibody-drug conjugates (ADCs) is a promising anti-cancer strategy that in order to be realized must overcome several obstacles, including identification ofExpand
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TEM8 interacts with the cleaved C5 domain of collagen alpha 3(VI).
Tumor endothelial marker (TEM)8 was uncovered as a gene expressed predominantly in tumor endothelium, and its protein product was recently identified as the receptor for anthrax toxin. Here, weExpand
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Identification of a Binding Partner for the Endothelial Cell Surface Proteins TEM7 and TEM7R
Tumor endothelial marker 7 (TEM7) was recently identified as an mRNA transcript overexpressed in the blood vessels of human solid tumors. Here, we identify several new variants of TEM7, derived byExpand
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TEM8/ANTXR1 blockade inhibits pathological angiogenesis and potentiates tumoricidal responses against multiple cancer types.
Current antiangiogenic agents used to treat cancer only partially inhibit neovascularization and cause normal tissue toxicities, fueling the need to identify therapeutic agents that are moreExpand
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