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INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in human and mouse
It is reported that mice deficient for the lipid 5-phosphatase Inpp5e develop a multiorgan disorder associated with structural defects of the primary cilium, and the results show that INPP5E plays an essential role in the primarycilium by controlling ciliary growth factor and PI3K signaling and stability. Expand
Phosphoinositides Regulate Ciliary Protein Trafficking to Modulate Hedgehog Signaling.
Primary cilia interpret vertebrate Hedgehog (Hh) signals and regulate ciliary membrane phosphoinositide composition, and Tulp3 reads out ciliaryosphoinositides to control ciliary protein localization, enabling Hh signaling. Expand
Modulation of Ciliary Phosphoinositide Content Regulates Trafficking and Sonic Hedgehog Signaling Output.
The link between ciliary regulation of phosphoinositides by INPP5E and Shh regulation via ciliary trafficking of TULP3/Gpr161 is revealed and mechanistic insight into ciliary alterations found in Joubert and MORM syndromes resulting from IN PP5E mutations is provided. Expand
Expression of members of the putative olfactory receptor gene family in mammalian germ cells
The finding suggests that a common receptor gene family encodes olfactory receptors and sperm cell receptors that could be involved in chemotaxis during fertilization. Expand
The lipid phosphatase SHIP2 controls insulin sensitivity
The results show that SHIP2 is a potent negative regulator of insulin signalling and insulin sensitivity in vivo. Expand
Inositol 1,3,4,5-tetrakisphosphate is essential for T lymphocyte development
The data indicate that Itpkb and Ins(1,3,4,5)P4 define an essential signaling pathway for T cell precursor responsiveness and development. Expand
Impaired motor coordination and Purkinje cell excitability in mice lacking calretinin.
Results show that calretinin plays a major role at the network level in cerebellar physiology as well as in slices, indicating that marked modifications of the firing behavior in vivo can be undetectable in slice. Expand
Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species.
The male germ line from each mammalian species tested is characterized by a specific repertoire of olfactory receptors, which display a pattern of expression suggestive of their potential implication in the control of sperm maturation, migration, or fertilization. Expand
Mutations in the inositol polyphosphate-5-phosphatase E gene link phosphatidyl inositol signaling to the ciliopathies
Phosphotidylinositol (PtdIns) signaling is tightly regulated both spatially and temporally by subcellularly localized PtdIns kinases and phosphatases that dynamically alter downstream signalingExpand
Altered Neuronal Excitability in Cerebellar Granule Cells of Mice Lacking Calretinin
The observed alterations of granule cell excitability can be explained by a decreased cytosolic calcium-buffering capacity resulting from the absence of calretinin, which suggests that calcium-binding proteins modulate intrinsic neuronal excitability and may therefore play a role in information processing in the CNS. Expand