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tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors.
- S. Berghmans, Ryan D. Murphey, +10 authors A. Look
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 11 January 2005
TP53 is the most frequently mutated tumor suppressor gene in human cancer, with nearly 50% of all tumors exhibiting a loss-of-function mutation. To further elucidate the genetic pathways involving… Expand
The molecular nature of zebrafish swirl: BMP2 function is essential during early dorsoventral patterning.
- Y. Kishimoto, K. H. Lee, L. Zon, M. Hammerschmidt, S. Schulte-Merker
- Biology, Medicine
- 15 November 1997
Early dorsoventral pattern formation in vertebrate embryos is regulated by opposing activities of ventralizing bone morphogenetic proteins (BMPs) and dorsal-specific BMP antagonists such as Chordin,… Expand
ccbe1 is required for embryonic lymphangiogenesis and venous sprouting
Lymphatic vessels have important roles in fluid homeostasis, fat absorption, inflammation and cancer metastasis and develop in a dynamic process (called lymphangiogenesis) involving budding,… Expand
The development of the paired fins in the Zebrafish (Danio rerio)
In the present study, we describe the structure and normal development of the zebrafish (Danio rerio) paired fins. Particularly, we focus on the structure of the apical epidermis and on endoskeletal… Expand
Vegfc/Flt4 signalling is suppressed by Dll4 in developing zebrafish intersegmental arteries
The development of arteries, veins and lymphatics from pre-existing vessels are intimately linked processes controlled by a number of well-studied reiteratively acting signalling pathways. To… Expand
Early Endocardial Morphogenesis Requires Scl/Tal1
The primitive heart tube is composed of an outer myocardial and an inner endocardial layer that will give rise to the cardiac valves and septa. Specification and differentiation of these two cell… Expand
MicroRNA-24 Regulates Vascularity After Myocardial Infarction
Background— Myocardial infarction leads to cardiac remodeling and development of heart failure. Insufficient myocardial capillary density after myocardial infarction has been identified as a critical… Expand
Reverse genetic screening reveals poor correlation between morpholino-induced and mutant phenotypes in zebrafish.
The widespread availability of programmable site-specific nucleases now enables targeted gene disruption in the zebrafish. In this study, we applied site-specific nucleases to generate zebrafish… Expand
Bone regenerates via dedifferentiation of osteoblasts in the zebrafish fin.
While mammals have a limited capacity to repair bone defects, zebrafish can completely regenerate amputated bony structures of their fins. Fin regeneration is dependent on formation of a blastema, a… Expand
Signals from the yolk cell induce mesoderm, neuroectoderm, the trunk organizer, and the notochord in zebrafish.
We have analyzed the role of the zebrafish yolk cell in the processes of mesoderm induction and establishment of the organizer. By recombining blastomere-free yolk cells and animal cap tissue we have… Expand