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Chemogenomic profiling on a genome-wide scale using reverse-engineered gene networks
An integrated computational-experimental approach for computing the likelihood that gene products and associated pathways are targets of a compound by filtering the mRNA expression profile of compound-exposed cells using a reverse-engineered model of the cell's gene regulatory network is presented. Expand
The transcription factor LSF: a novel oncogene for hepatocellular carcinoma.
A high throughput screening identified small molecule inhibitors of LSF DNA binding and the prototype of these molecules, Factor Quinolinone inhibitor 1 (FQI1), profoundly inhibited cell viability and induced apoptosis in human HCC cells without exerting harmful effects to normal immortal human hepatocytes and primary mouse hepatocytes. Expand
Highly selective hydrolytic kinetic resolution of terminal epoxides catalyzed by chiral (salen)Co(III) complexes. Practical synthesis of enantioenriched terminal epoxides and 1,2-diols.
The hydrolytic kinetic resolution (HKR) of terminal epoxides catalyzed by chiral (salen)Co(III) complex 1 x OAc affords both recovered unreacted epoxide and 1,2-diol product in highly enantioenrichedExpand
Asymmetric allylboration of acyl imines catalyzed by chiral diols.
Mechanistic investigations of the allylboration reaction including IR, NMR, and mass spectrometry studies indicate that acyclic boronates are activated by chiral diols via exchange of one of the bor onate alkoxy groups with activation of the acyl imine via hydrogen bonding. Expand
Enantioselective Synthesis of Allenes by Catalytic Traceless Petasis Reactions.
An asymmetric boronate addition to sulfonyl hydrazones catalyzed by chiral biphenols to access enantioenriched allenes in a traceless Petasis reaction is reported, yielding a propargylic diazene that performs an alkyne walk to afford the allene. Expand
Antiproliferative small-molecule inhibitors of transcription factor LSF reveal oncogene addiction to LSF in hepatocellular carcinoma
It is concluded that LSF is the specific biological target of FQIs, and the findings support the further development of LSF inhibitors for cancer chemotherapy. Expand
Network-based prediction for sources of transcriptional dysregulation using latent pathway identification analysis
LPIA can successfully identify pathways whose perturbations have latent influences on the transcriptionally altered genes and is shown to be effective through analysis of data on metastatic cancer progression, drug treatment in human lung carcinoma cells, and diagnosis of type 2 diabetes. Expand
An in vitro comparison of shear bond strength of zirconia to enamel using different surface treatments.
Airborne-particle abrasion followed by the application of a zirconia primer produced the highest bond strength to enamel, and can be recommended as a promising surface treatment method to achieve a durable bond to densely sintered zIRconia ceramics. Expand
Asymmetric Petasis Borono-Mannich Allylation Reactions Catalyzed by Chiral Biphenols.
Chiral biphenols catalyze the asymmetric Petasis borono-Mannich allylation of aldehydes and amines through the use of a bench-stable allyldioxaborolane, which results in stereodivergent products with anti- and syn-diastereomers both in good diastereoselectivities and enantioselectivity from the corresponding E- and Z-borolane stereoisomers. Expand