• Publications
  • Influence
Positive selection of primate TRIM5alpha identifies a critical species-specific retroviral restriction domain.
Primate genomes encode a variety of innate immune strategies to defend themselves against retroviruses. One of these, TRIM5alpha, can restrict diverse retroviruses in a species-specific manner. Thus,Expand
  • 607
  • 52
  • PDF
Ancient Adaptive Evolution of the Primate Antiviral DNA-Editing Enzyme APOBEC3G
Host genomes have adopted several strategies to curb the proliferation of transposable elements and viruses. A recently discovered novel primate defense against retroviral infection involves aExpand
  • 432
  • 24
  • PDF
Discordant Evolution of the Adjacent Antiretroviral Genes TRIM22 and TRIM5 in Mammals
TRIM5α provides a cytoplasmic block to retroviral infection, and orthologs encoded by some primates are active against HIV. Here, we present an evolutionary comparison of the TRIM5 gene to itsExpand
  • 160
  • 20
  • PDF
High-Frequency Persistence of an Impaired Allele of the Retroviral Defense Gene TRIM5α in Humans
The intracellular TRIM5alpha protein successfully inhibits HIV-1 infection in rhesus monkeys, but not in humans . A few amino acids in the virus-interacting SPRY domain were found to be responsibleExpand
  • 106
  • 14
Understanding Biases in Ribosome Profiling Experiments Reveals Signatures of Translation Dynamics in Yeast
Ribosome profiling produces snapshots of the locations of actively translating ribosomes on messenger RNAs. These snapshots can be used to make inferences about translation dynamics. Recent ribosomeExpand
  • 150
  • 12
  • PDF
High-throughput DNA sequencing errors are reduced by orders of magnitude using circle sequencing
Significance This paper presents a library preparation method that dramatically improves the error rate associated with high-throughput DNA sequencing and is substantially more cost-effective thanExpand
  • 214
  • 8
  • PDF
HIV-1 Capsid-Targeting Domain of Cleavage and Polyadenylation Specificity Factor 6
ABSTRACT The antiviral factor CPSF6-358 restricts human immunodeficiency virus type 1 (HIV-1) infection through an interaction with capsid (CA), preventing virus nuclear entry and integration. HIV-1Expand
  • 61
  • 8
Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats
Biological factors that influence the host range and spillover of Ebola virus (EBOV) and other filoviruses remain enigmatic. While filoviruses infect diverse mammalian cell lines, we report thatExpand
  • 72
  • 7
Molecular evolution of the antiretroviral TRIM5 gene
In 2004, the first report of TRIM5α as a cellular antiretroviral factor triggered intense interest among virologists, particularly because some primate orthologs of TRIM5α have activity against HIV.Expand
  • 104
  • 6
Mcm10 and Cdc45 cooperate in origin activation in Saccharomyces cerevisiae.
Mcm10 has recently been found to play a crucial role in multiple steps of the DNA replication initiation process in eukaryotes. Here, we have examined the role of Mcm10 in assembling initiationExpand
  • 86
  • 6