Possible emergence of new geminiviruses by frequent recombination.
- M. Padidam, S. Sawyer, C. Fauquet
- BiologyVirology
- 20 December 1999
Geminiviruses are a group of plant viruses characterized by a genome of circular single-stranded DNA encapsidated in twinned quasi-isometric particles and recombination is very frequent and occurs between species and within and across genera.
Positive selection of primate TRIM5alpha identifies a critical species-specific retroviral restriction domain.
- S. Sawyer, Lily I. Wu, M. Emerman, Harmit S. Malik
- BiologyProceedings of the National Academy of Sciences…
- 22 February 2005
This study finds strong evidence for ancient positive selection in the primate TRIM5alpha gene and shows that this patch is generally essential for retroviral restriction and is responsible for most of the species-specific antiretroviral restriction activity.
Ancient Adaptive Evolution of the Primate Antiviral DNA-Editing Enzyme APOBEC3G
- S. Sawyer, M. Emerman, Harmit S. Malik
- BiologyPLoS Biology
- 20 July 2004
It is shown that the APOBEC3G gene has been subject to strong positive selection throughout the history of primate evolution, and appears more ancient than, and is likely only partially caused by, modern lentiviruses.
Discordant Evolution of the Adjacent Antiretroviral Genes TRIM22 and TRIM5 in Mammals
- S. Sawyer, M. Emerman, Harmit S. Malik
- BiologyPLoS Pathogens
- 1 December 2007
A striking congruence is found in the positions of amino acid residues found to be under positive selection in both TRIM5α and TRIM22, which in both proteins fall predominantly in the β2-β3 surface loop of the B30.2 domain, indicating that this small structural loop is a viral recognition motif spanning a hundred million years of mammalian evolution.
Mcm10 and the MCM2-7 complex interact to initiate DNA synthesis and to release replication factors from origins.
- L. Homesley, M. Lei, Y. Kawasaki, S. Sawyer, T. Christensen, B. Tye
- Biology, ChemistryGenes & Development
- 15 April 2000
It is shown that Mcm10 is a chromatin-associated protein that mediates the association of the MCM2-7 complex with replication origins and that interaction between Mcm 10 and Mcm7 is required for proper replication initiation and prompt release of origin-bound factors.
Understanding Biases in Ribosome Profiling Experiments Reveals Signatures of Translation Dynamics in Yeast
- Jeffrey A. Hussmann, Stephanie Patchett, Arlen W. Johnson, S. Sawyer, W. Press
- BiologybioRxiv
- 1 October 2015
It is shown that in all such experiments, codons decoded by less abundant tRNAs were in fact being translated more slowly before the addition of CHX disrupted these dynamics, suggesting that conclusions from experiments in yeast using CHX may need reexamination.
Species-Specific Deamidation of cGAS by Herpes Simplex Virus UL37 Protein Facilitates Viral Replication.
- Junjie Zhang, Jun Zhao, P. Feng
- BiologyCell Host and Microbe
- 1 August 2018
High-Frequency Persistence of an Impaired Allele of the Retroviral Defense Gene TRIM5α in Humans
- S. Sawyer, Lily I. Wu, J. Akey, M. Emerman, Harmit S. Malik
- BiologyCurrent Biology
- 10 January 2006
Nuclear TRIM25 Specifically Targets Influenza Virus Ribonucleoproteins to Block the Onset of RNA Chain Elongation.
- N. R. Meyerson, Ligang Zhou, S. Sawyer
- BiologyCell Host and Microbe
- 8 November 2017
Mcm10 and Cdc45 cooperate in origin activation in Saccharomyces cerevisiae.
- S. Sawyer, Irene H Cheng, Weihang Chai, B. Tye
- BiologyJournal of Molecular Biology
- 2 July 2004
...
...