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Liposomal sustained-release delivery systems for intravenous injection. III. Antitumor activity of lipophilic mitomycin C prodrug-bearing liposomes.
An intravenously injectable sustained-release delivery system for mitomycin C (MMC) was prepared by formulating a lipophilic MMC prodrug, N-(cholesteryloxycarbonyl)glycyl MMC (COCG-MMC), inExpand
Liposomal sustained-release delivery systems for intravenous injection. I. Physicochemical and biological properties of newly synthesized lipophilic derivatives of mitomycin C.
1a-N-Stearoyl mitomycin C (MMC) and six 1a-N-substituted derivatives of MMC possessing the cholesteryl moiety with different spacers were synthesized, and their biopharmaceutical properties wereExpand
Liposomal sustained-release delivery systems for intravenous injection. II. Design of liposome carriers and blood disposition of lipophilic mitomycin C prodrug-bearing liposomes.
Various types of unilamellar liposomes possessing a narrow size distribution were prepared by controlled dialysis and their blood clearance was studied in mice and rats to assess their suitability asExpand
Liposomal sustained-release delivery systems for intravenous injection V. Biological disposition of liposome-entrapped lipophilic prodrug of 1-beta-D-arabinofuranosylcytosine.
A lipophilic prodrug of 1-β-D-arabinofuranosylcytosine (Ara-C), N4-[N-(cholesteryloxycarbonyl) glycyl]-Ara-C (COCG-Ara-C) was entrapped in unilamellar liposomes or solubilized in pH 7.4Expand
Deactivation of a Cu/Al2O3 Catalyst in a N2O Decomposition Reaction
Dinitrogen oxide (nitrous oxide, N2O), a non-CO2 greenhouse gas, is produced as a by-product in the oxidation of cyclohexanone and cyclohexanol with nitric acid in adipic acid production plants. AExpand