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Effect of Antisense Oligonucleotides against Cholesteryl Ester Transfer Protein on the Development of Atherosclerosis in Cholesterol-fed Rabbits*
Cholesteryl ester transfer protein (CETP) is the enzyme that facilitates the transfer of cholesteryl ester from high density lipoprotein (HDL) to apolipoprotein B (apoB)-containing lipoproteins.…
Interaction of mRNAs for angiotensin II type 1 and type 2 receptors to vascular remodeling in spontaneously hypertensive rats.
- S. Otsuka, M. Sugano, N. Makino, S. Sawada, T. Hata, Y. Niho
- Biology, MedicineHypertension
- 1 September 1998
Results indicate that AT1 receptor, but not AT2 receptors, plays a crucial role in the remodeling of matrix tissue, while AT2 receptor may play a roles in the development of hypertrophy of smooth muscle in aorta in SHR, and that the reduction of hyperTrophy of smoother muscle does not fully account for the suppression of hypertension.
Low density lipoproteins develop resistance to oxidative modification due to inhibition of cholesteryl ester transfer protein by a monoclonal antibody.
CETP inhibition reduces the composition of CE and TG in LDL and makes the LDL resistant to oxidation, as well as preventing the formation of conjugated dienes.
Intravenous injection with antisense oligodeoxynucleotides against angiotensinogen decreases blood pressure in spontaneously hypertensive rats.
Results showed that intravenous injection with antisense ODNs against angiotensinogen coupled to asialoglycoprotein carrier molecules targeted to the liver could thus inhibit plasma angiotenogen levels and, as a result, induce a decrease in blood pressure in SHR.
Chronic antisense therapy for angiotensinogen on cardiac hypertrophy in spontaneously hypertensive rats.
Secretion of preβ HDL increases with the suppression of cholesteryl ester transfer protein in Hep G2 cells
Reduction of plasma angiotensin II to normal levels by antisense oligodeoxynucleotides against liver angiotensinogen cannot completely attenuate vascular remodeling in spontaneously hypertensive rats
Plasma AGT is considered to play a role in the development of hypertrophy of smooth muscle in the aorta of SHRs, it is thought to have only a slight effect, however, on the remodeling of the matrix tissue when the suppression of hypertension is insufficient.
Secretion of prebeta HDL increases with the suppression of cholesteryl ester transfer protein in Hep G2 cells.
The suppression of hepatic CETP by antisense oligodeoxynucleotides against CETP targeted to the liver on the secretion of apo A-I using a Hep G2 cell culture indicated the possibility that the original level of prebeta HDL is sufficient in such patients with CETP deficiency.