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Polyhydroxy surfactants for the formulation of lipid nanoparticles (SLN and NLC): effects on size, physical stability and particle matrix structure.
Data show that surfactants have a distinct influence on the particle matrix structure (and related stability and drug loading), to which too little attention was given by now.
Evaluation of Anticancer and Antioxidant Activity of a Commercially Available CO2 Supercritical Extract of Old Man’s Beard (Usnea barbata)
Investigation of chemical profile and stated biological activities of the supercritical CO2 extract of old man’s beard compared to the extracts obtained using the conventional techniques found a good correlation of usnic acid content in the extracts and their antioxidant capacity was established, extricating SCE as the most active one.
A combined approach in characterization of an effective w/o hand cream: the influence of emollient on textural, sensorial and in vivo skin performance
A modified sensory study could be useful for fast in‐line screening along with instrumental characterization of a novel cosmetic emulsion product and could be particularly helpful in the process of distinguishing a single formulation from several differing in one component.
Biocompatible microemulsions of a model NSAID for skin delivery: A decisive role of surfactants in skin penetration/irritation profiles and pharmacokinetic performance.
Sugar-based excipients increased delivery of aceclofenac through stratum corneum by increasing its fluidity, showing overall more satisfying safety profiles, and sucrose ester-based microemulsions proved to be promising carriers for dermal/transdermal acecl ofenac delivery.
Solid lipid nanoparticles (SLN) stabilized with polyhydroxy surfactants: Preparation, characterization and physical stability investigation
Abstract Polyhydroxy surfactants are nonionic ethylene oxide free stabilizers known for their complimentary dermatological properties and favorable environmental profile. The aim of this study was to
An Overview of Novel Surfactants for Formulation of Cosmetics with Certain Emphasis on Acidic Active Substances
Abstract Novel surfactants which are nowadays available for incorporation into various formulations of personal care and cosmetic products are numerous, implying a permanent need for their
pH-sensitive microparticles for oral drug delivery based on alginate/oligochitosan/Eudragit(®) L100-55 "sandwich" polyelectrolyte complex.
It was found that reinforcement of the ALG-OCH particles with OCH-EL PEC had no significant effect on the relatively high encapsulation efficiencies and suggested that alginate-oligochitosan-Eudragit L100-55 microparticles have promising potential as pH-sensitive multiparticulate drug carriers for oral delivery of NSAIDs.
Tacrolimus loaded biocompatible lecithin-based microemulsions with improved skin penetration: Structure characterization and in vitro/in vivo performances.
Development of potentially non-irritant, lecithin-based microemulsions containing ethanol, isopropanol and/or propylene glycol as cosurfactants, varying caprylic/capric triglycerides and propylene Glycol monocaprylate as oil phase is developed.
An alkyl polyglucoside-mixed emulsifier as stabilizer of emulsion systems: the influence of colloidal structure on emulsions skin hydration potential.
Different emulsion samples exhibited different water distribution modes in the structure, reflecting their rheological behavior and also their skin hydration capacity, as well as the emulsifier/water ratios.
Experimental design in formulation of diazepam nanoemulsions: physicochemical and pharmacokinetic performances.
Fast and intense initial distribution into rat brain of diazepam from nanoemulsions with 20% and 30% oil content is demonstrated, suggesting their applicability in urgent situations, and interactions among the investigated factors, rather than factors alone, were shown to more profoundly affect nanoemulsion characteristics.