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Sodium glucose cotransporter 2 inhibitor canagliflozin attenuates liver cancer cell growth and angiogenic activity by inhibiting glucose uptake
Sodium‐glucose cotransporter 2 inhibitors (SGLT2‐Is) comprise a new class of antidiabetic agents that inhibit glucose reabsorption in the renal proximal tubules. Although a recent report demonstratedExpand
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Temporal profile of neurogenesis in the subventricular zone, dentate gyrus and cerebral cortex following transient focal cerebral ischemia
Abstract Background: In the adult mammalian brain, it is considered that neurogenesis persists in limited regions such as the hippocampal dentate gyrus (DG) and the subventricular zone (SVZ) of theExpand
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Interleukin 2 receptor α chain gene polymorphisms and risks of multiple sclerosis and neuromyelitis optica in southern Japanese
BACKGROUND Interleukin 2 receptor α subunit (IL2RA) is a genetic risk for multiple sclerosis (MS) in Caucasians. However, the association between MS and IL2RA in Japanese idiopathic demyelinatingExpand
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The masticatory organ and stress management
SummaryIn humans, the strong grinding and clenching function of the masticatory muscles known as bruxism has been thought to play an important role in mitigating stress-induced psychosomaticExpand
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Coexpression of organic anion‐transporting polypeptides 1B3 and multidrug‐resistant proteins 2 increases the enhancement effect of gadolinium‐ethoxybenzyl‐diethylenetriamine pentaacetic acid on
We aimed to elucidate the relationship between the contrast enhancement effect of gadolinium‐ethoxybenzyl‐diethylenetriamine pentaacetic acid (Gd‐EOB‐DTPA) on magnetic resonance imaging (MRI) ofExpand
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Angiotensin receptor blockade attenuates cholangiocarcinoma cell growth by inhibiting the oncogenic activity of Yes-associated protein.
Cholangiocarcinoma (CCA) is a destructive malignancy with limited responsiveness to conventional chemotherapy. Although angiotensin receptor blockers (ARBs) have gained attention for their potentialExpand
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Predictive parameter of tolvaptan effectiveness in cirrhotic ascites
The efficacy of the vasopressin V2 receptor antagonist tolvaptan for difficult‐to‐treat cirrhotic ascites has recently been reported. However, its effect is variable among patients. This study aimedExpand
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JCOG0504: A phase III randomized trial of surgery with whole brain radiation therapy versus surgery with salvage stereotactic radiosurgery in patients with 1 to 4 brain metastases.
2003Background: Whether salvage stereotactic radiosurgery (SRS) alone is effective for patients with brain metastases (BM) is not yet clarified, although clinical benefits such as better preservationExpand
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Clinical significance of the Scheuer histological staging system for primary biliary cholangitis in Japanese patients
Background Inadequate response to ursodeoxycholic acid (UDCA) is associated with unfavorable outcomes in patients with primary biliary cholangitis (PBC). We aimed to identify surrogate markers forExpand
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Aortic Valve Replacement for the Management of Heyde Syndrome: A Case Report.
Heyde syndrome describes the triad of aortic stenosis, acquired coagulopathy, and anemia due to bleeding from intestinal angiodysplasia. An 87-year-old man with iron deficiency anemia due to melenaExpand
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