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The Junctional Adhesion Molecule 3 (JAM-3) on Human Platelets is a Counterreceptor for the Leukocyte Integrin Mac-1
Human JAM-3 was identified and described as a novel counterreceptor on platelets for the leukocyte β2-integrin Mac-1 and provides a novel molecular target for antagonizing interactions between vascular cells that promote inflammatory vascular pathologies such as in atherothrombosis. Expand
Zwa-NAT was clinically the more severe (14% had intracranial haemorrhages) and responded well to either maternal platelet transfusions or intravenous IgG and most children recovered without specific therapy. Expand
The Junctional Adhesion Molecule-C Promotes Neutrophil Transendothelial Migration in Vitro and in Vivo*
JAM-C participates in neutrophil transmigration and thereby provides a novel molecular target for antagonizing interactions between vascular cells that promote inflammatory vascular pathologies. Expand
Junctional adhesion molecule-C regulates vascular endothelial permeability by modulating VE-cadherin–mediated cell–cell contacts
Together, through modulation of endothelial contractility and VE-cadherin–mediated adhesion, JAM-C helps to regulate vascular permeability and pathologic angiogenesis. Expand
Junctional adhesion molecules (JAM)-B and -C contribute to leukocyte extravasation to the skin and mediate cutaneous inflammation.
Combined antibody treatment at doses of 1.25 mg per kg bodyweight lead to additive inhibition of allergic contact dermatitis, indicating that JAM-B and -C may have distinct functions. Expand
Nucleotide polymorphisms in the alpha2 gene define multiple alleles that are associated with differences in platelet alpha2 beta1 density.
It is shown here that the rate of platelet attachment to type I collagen in whole blood under conditions of high shear rate is proportional to the density of alpha2beta1 receptors on the platelet surface, which could have an important impact on platelet adhesion to collagen in both whole blood and in vivo. Expand
A variable number of tandem repeats polymorphism influences the transcriptional activity of the neonatal Fc receptor α‐chain promoter
Data indicate that a VNTR promoter polymorphism influences the expression of the FcRn receptor, leading to different IgG‐binding capacities. Expand
Molecular basis of the neutrophil glycoprotein NB1 (CD177) involved in the pathogenesis of immune neutropenias and transfusion reactions
The human granulocyte alloantigen NB1, recently clustered as CD177, is heterogenously expressed on neutrophils of 88–97% of healthy individuals. Since its molecular nature has remained unknown, weExpand
348 cases of suspected neonatal alloimmune thrombocytopenia
Indicators favored bolus tocolysis but were not statistically significant: a longer gestational period, fewer infants weighing < 2500 gm, and a lower incidence of respiratory distress syndrome. Expand
A Hydrophobic Patch on Proteinase 3, the Target of Autoantibodies in Wegener Granulomatosis, Mediates Membrane Binding via NB1 Receptors*
It is hypothesized that the unique hydrophobic cluster of PR3 that is not present on human neutrophil elastase and cathepsin G and presumably is also missing in other human PR3 homologs accounts for its binding to the NB1 receptor expressed on the cellular surface of NB1 cells. Expand