• Publications
  • Influence
Network dynamics of the brain and influence of the epileptic seizure onset zone
Significance In epilepsy, seizures elicit changes in the functional connectivity of the brain that shed insight into the seizures’ nature and onset zone. We investigated the brain connectivity ofExpand
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Closed-Loop Control of Deep Brain Stimulation: A Simulation Study
Deep brain stimulation (DBS) is an effective therapy to treat movement disorders including essential tremor, dystonia, and Parkinson's disease. Despite over a decade of clinical experience theExpand
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Task-Independent Cognitive State Transition Detection From Cortical Neurons During 3-D Reach-to-Grasp Movements
TLDR
We propose a real-time (online) task-independent (TI) framework to detect cognitive state transitions from spike trains and kinematic measurements. Expand
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Quickest detection of drug-resistant seizures: An optimal control approach
Epilepsy affects 50 million people worldwide, and seizures in 30% of the cases remain drug resistant. This has increased interest in responsive neurostimulation, which is most effective whenExpand
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Reinforcement mechanisms in putamen during high frequency STN DBS: A point process study
TLDR
We analyze the activity of the putamen in a monkey by combining single unit recordings and point process models.Despite a pivotal role in the motor loop, dorsolateral striatum (putamen) has been poorly studied thus far under Parkinsonian conditions and Deep Brain Stimulation . Expand
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Role of cerebellar GABAergic dysfunctions in the origins of essential tremor
Significance We investigated the mechanisms of tremor generation in essential tremor (ET). Using computational modeling we show that tremor-related activity can originate from the olivocerebellarExpand
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Systems Approaches to Optimizing Deep Brain Stimulation Therapies in Parkinson’s Disease
Over the last 30 years, deep brain stimulation (DBS) has been used to treat chronic neurological diseases like dystonia, obsessive–compulsive disorders, essential tremor, Parkinson’s disease, andExpand
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State Dynamics of the Epileptic Brain
Communication between specialized regions of the brain is a dynamic process allowing for different connections to accomplish different tasks. While the content of interregional communication isExpand
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Therapeutic mechanisms of high-frequency stimulation in Parkinson’s disease and neural restoration via loop-based reinforcement
Significance We investigated the therapeutic mechanisms of high-frequency stimulation (HFS) in Parkinson’s disease by developing a computational model of the cortico-basal ganglia-thalamo-corticalExpand
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Decision Support System for Seizure Onset Zone Localization Based on Channel Ranking and High-Frequency EEG Activity
TLDR
We propose a rank-based solution to identify the seizure onset zone by using the HFO in multichannel intracranial EEG. Expand
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