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Essential Roles of E3 Ubiquitin Ligases in p53 Regulation
  • S. Sane, K. Rezvani
  • Chemistry, Medicine
  • International journal of molecular sciences
  • 1 February 2017
This review provides a comprehensive understanding of p53 regulation by selective E3 ubiquitin ligases and their potential to be considered as a new class of biomarkers and therapeutic targets in diverse types of cancers. Expand
Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells
UBXN2A is introduced as a home defense response protein, which can reconstitute inactive p53-dependent apoptotic pathways and inhibit the binding between mot-2 and p53, which is an attractive therapeutic strategy in mot- 2-elevated tumors. Expand
A plant alkaloid, veratridine, potentiates cancer chemosensitivity by UBXN2A-dependent inhibition of an oncoprotein, mortalin-2
The VTD-dependent expression of UBXN2A is a potential candidate for designing novel strategies for colon cancer treatment, and VTD or its modified analogs offer a valuable adjuvant chemotherapy strategy to improve the efficacy of 5-FU-based chemotherapy for Colon cancer patients harboring WT-p53. Expand
Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy
Details are provided into the mechanistic role of UBXN2A as a potent mortalin inhibitor and as a potential chemotherapy sensitizer for clinical application and how three amino acids within the substrate-binding domain of mortalin are crucial for UBxN 2A binding to mortalin. Expand
Nucleocytoplasmic Translocation of UBXN2A Is Required for Apoptosis during DNA Damage Stresses in Colon Cancer Cells
It is shown that nucleocytoplasmic translocation of UBXN2A in response to stresses is necessary for its anti-cancer function in the cy toplasm, as well as activation of other mot-2-dependent growth promoting pathways. Expand
UBXN2A enhances CHIP‐mediated proteasomal degradation of oncoprotein mortalin‐2 in cancer cells
The existence of a multiprotein complex containing UBXN2A, CHIP, and mot‐2 suggests a synergistic tumor suppressor activity of UBxN 2A and CHIP in mot‐ 2‐enriched tumors, and validates the UB XN2a‐CHIP axis as a novel and potential therapeutic target in CRC. Expand
Nucleocytoplasmic Translocation of UBXN 2 A Is Required for Apoptosis during DNA Damage Stresses in Colon Cancer Cells
The subcellular localization, expression level, and activity of anti-cancer proteins alter in response to intrinsic and extrinsic cellular stresses to reverse tumor progression. The purpose of thisExpand