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Most genetic risk for autism resides with common variation
TLDR
Autism's genetic architecture is reached: its narrow-sense heritability is ∼52.4%, with most due to common variation, and rare de novo mutations contribute substantially to individual liability, yet their contribution to variance in liability, 2.6%, is modest compared to that for heritable variation.
The familial risk of autism.
TLDR
Among children born in Sweden, the individual risk of ASD and autistic disorder increased with increasing genetic relatedness and support for a disease etiology including only additive genetic and nonshared environmental effects was found.
Analysis of shared heritability in common disorders of the brain
TLDR
It is demonstrated that, in the general population, the personality trait neuroticism is significantly correlated with almost every psychiatric disorder and migraine, and it is shown that both psychiatric and neurological disorders have robust correlations with cognitive and personality measures.
Identification of common genetic risk variants for autism spectrum disorder
TLDR
A genome-wide association meta-analysis of 18,381 austim spectrum disorder cases and 27,969 controls identifies five risk loci and the authors find quantitative and qualitative polygenic heterogeneity across ASD subtypes.
Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism
TLDR
The largest exome sequencing study of autism spectrum disorder (ASD) to date, using an enhanced analytical framework to integrate de novo and case-control rare variation, identifies 102 risk genes at a false discovery rate of 0.1 or less, consistent with multiple paths to an excitatory-inhibitory imbalance underlying ASD.
Advancing paternal age and risk of autism: new evidence from a population-based study and a meta-analysis of epidemiological studies
TLDR
Findings provide the strongest evidence to date that advanced paternal age is a risk factor for autism in the offspring and possible biological mechanisms include de novo aberration and mutations or epigenetic alterations associated with aging.
The increasing prevalence of reported diagnoses of childhood psychiatric disorders: a descriptive multinational comparison
TLDR
The results highlight the increase in the last 20 years in the number of children and families in contact with health care systems for diagnosis and services for an array of childhood neuropsychiatric disorders, a phenomenon not limited to ASD.
Advancing paternal age and bipolar disorder.
TLDR
An association between paternal age and risk for BPD in the offspring of older men was noted and the risk increased with advancing paternal age, consistent with the hypothesis that advanced paternal age increases the risk for de novo mutations in susceptibility genes for neurodevelopmental disorders.
Advancing maternal age is associated with increasing risk for autism: a review and meta-analysis.
TLDR
An association between advancing maternal age and risk of autism is supported, and the meta-regression suggested a stronger maternal age effect in the studies with more male offspring and for children diagnosed in later years.
Low carbohydrate-high protein diet and incidence of cardiovascular diseases in Swedish women: prospective cohort study
TLDR
Low carbohydrate-high protein diets, used on a regular basis and without consideration of the nature of carbohydrates or the source of proteins, are associated with increased risk of cardiovascular disease.
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