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Neuronal palmitoyl acyl transferases exhibit distinct substrate specificity
Palmitoylation, a post‐translational modification of cysteine residues with the lipid palmitate, has recently emerged as an important mechanism for regulating protein trafficking and function. WithExpand
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Altered palmitoylation and neuropathological deficits in mice lacking HIP14.
Huntingtin interacting protein 14 (HIP14, ZDHHC17) is a huntingtin (HTT) interacting protein with palmitoyl transferase activity. In order to interrogate the function of Hip14, we generated mice withExpand
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Wild-type HTT modulates the enzymatic activity of the neuronal palmitoyl transferase HIP14.
Huntington disease (HD) is caused by polyglutamine expansion in the huntingtin (HTT) protein. Huntingtin-interacting protein 14 (HIP14), one of 23 DHHC domain-containing palmitoyl acyl transferasesExpand
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Tracking brain palmitoylation change: predominance of glial change in a mouse model of Huntington's disease.
Protein palmitoylation, a reversible lipid modification of proteins, is widely used in the nervous system, with dysregulated palmitoylation being implicated in a variety of neurological disorders.Expand
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Putting proteins in their place: Palmitoylation in Huntington disease and other neuropsychiatric diseases
Post-translational modification of proteins by the lipid palmitate is critical for protein localization and function. Palmitoylation is regulated by the opposing enzymes palmitoyl acyltransferasesExpand
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Hip14l-deficient mice develop neuropathological and behavioural features of Huntington disease.
Palmitoylation, the dynamic post-translational addition of the lipid, palmitate, to proteins by Asp-His-His-Cys-containing palmitoyl acyltransferase (PAT) enzymes, modulates protein function andExpand
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The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease.
HIP14 is the most highly conserved of 23 human palmitoyl acyltransferases (PATs) that catalyze the post-translational addition of palmitate to proteins, including huntingtin (HTT). HIP14 isExpand
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Curation of the Mammalian Palmitoylome Indicates a Pivotal Role for Palmitoylation in Diseases and Disorders of the Nervous System and Cancers
We curated the data from 15 palmitoylation proteomics studies into one compendium containing 1,838 genes encoding palmitoylelated proteins; representing approximately 10% of the genome. Expand
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Aberrant palmitoylation in Huntington disease.
Huntington disease (HD) is an adult-onset neurodegenerative disease caused by a CAG expansion in the HTT gene. HD is characterized by striatal atrophy and is associated with motor, cognitive andExpand
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Palmitoylation of caspase-6 by HIP14 regulates its activation
Caspase-6 (CASP6) has an important role in axonal degeneration during neuronal apoptosis and in the neurodegenerative diseases Alzheimer and Huntington disease. Decreasing CASP6 activity may help toExpand
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