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PSA and beyond: alternative prostate cancer biomarkers
- S. Saini
- Cellular Oncology
- 20 January 2016
BackgroundThe use of biomarkers for prostate cancer screening, diagnosis and prognosis has the potential to improve the clinical management of the patients. Owing to inherent limitations of the… Expand
MicroRNA‐205–directed transcriptional activation of tumor suppressor genes in prostate cancer
MicroRNAs (miRNAs) are small noncoding RNAs that regulate the expression of approximately 60% of all human genes. They play important roles in numerous cellular processes, including development,… Expand
Genistein Inhibits Prostate Cancer Cell Growth by Targeting miR-34a and Oncogenic HOTAIR
Objective Genistein is a soy isoflavone that has antitumor activity both in vitro and in vivo. It has been shown that genistein inhibits many type of cancers including prostate cancer (PCa) by… Expand
Regulatory Role of mir-203 in Prostate Cancer Progression and Metastasis
Purpose: Advanced metastatic prostate cancer (PCa) is a fatal disease, with only palliative therapeutic options. Though almost 80% of cases of metastatic PCa present bone metastasis, our current… Expand
miR-23b represses proto-oncogene Src kinase and functions as methylation-silenced tumor suppressor with diagnostic and prognostic significance in prostate cancer.
The miRNAs have great potential as biomarkers and therapeutic agents owing to their ability to control multiple genes and potential to influence cellular behavior. Here, we identified that miR-23b is… Expand
Long Non-coding RNA HOTAIR Is Targeted and Regulated by miR-141 in Human Cancer Cells*
- T. Chiyomaru, S. Fukuhara, +9 authors S. Yamamura
- Biology, Medicine
- The Journal of Biological Chemistry
- 10 March 2014
Background: Silencing of long non-coding RNA (lncRNA) by microRNA (miRNA) has only been recently observed. Results: miR-141 binds to HOTAIR and suppresses its oncogenic function in Ago2… Expand
MicroRNA-23b Functions as a Tumor Suppressor by Regulating Zeb1 in Bladder Cancer
MicroRNAs (miRNAs) are small, non-coding RNAs that regulate gene expression by targeted repression of transcription and translation. In this study we show that miRNA-23b (miR-23b) acts as a tumor… Expand
BTG3 tumor suppressor gene promoter demethylation, histone modification and cell cycle arrest by genistein in renal cancer.
BTG3/ANA/APRO4 has been reported to be a tumor suppressor gene in some malignancies. It constitutes important negative regulatory mechanism for Src-mediated signaling, a negative regulator of the… Expand
Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.
The minichromosome maintenance (MCM) gene family is essential for DNA replication and is frequently upregulated in various cancers. Here, we examined the role of MCM2 in prostate cancer and the… Expand
MicroRNA-708 induces apoptosis and suppresses tumorigenicity in renal cancer cells.
Cancer pathogenesis is restricted by stresses that compromise cell division and survival. In this study, we identify miR-708, a little studied member of a set of microRNAs that have been implicated… Expand