• Publications
  • Influence
Smad3 is key to TGF-beta-mediated epithelial-to-mesenchymal transition, fibrosis, tumor suppression and metastasis.
Smads2 and 3 transduce signals of TGF-beta from the cell surface to the nucleus. We used mice with a targeted deletion of Smad3 to study the specific contributions of this signaling pathway toExpand
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Targeted disruption of TGF-beta1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction.
Tubulointerstitial fibrosis is the final common result of a variety of progressive injuries leading to chronic renal failure. Transforming growth factor-beta (TGF-beta) is reportedly upregulated inExpand
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  • Open Access
Smad3 signaling is required for epithelial-mesenchymal transition of lens epithelium after injury.
Lens epithelial cells undergo epithelial-mesenchymal transition (EMT) after injury as in cataract extraction, leading to fibrosis of the lens capsule. Fibrosis of the anterior capsule can be modeledExpand
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Role of Lumican in the Corneal Epithelium during Wound Healing*
Lumican regulates collagenous matrix assembly as a keratan sulfate proteoglycan in the cornea and is also present in the connective tissues of other organs and embryonic corneal stroma as aExpand
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TGFbeta pathobiology in the eye.
  • S. Saika
  • Medicine
  • Laboratory investigation; a journal of technical…
  • 2006
Transforming growth factor beta (TGFbeta), a multifunctional growth factor, is one of the most important ligands involved in the regulation of cell behavior in ocular tissues in physiological orExpand
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Smad3 is required for dedifferentiation of retinal pigment epithelium following retinal detachment in mice
Retinal pigment epithelial (RPE) cells dedifferentiate and undergo epithelial–mesenchymal transition (EMT) following retinal detachment, playing a central role in formation of fibrous tissue on theExpand
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  • Open Access
Adenovirus-mediated expression of BMP-7 suppresses the development of liver fibrosis in rats
Background: Liver cirrhosis, which is caused by the accumulation of extracellular matrix materials, is a serious clinical problem that can progress to hepatic failure. Transforming growth factor-βExpand
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Relationship between posterior capsule opacification and intraocular lens biocompatibility
  • S. Saika
  • Biology, Medicine
  • Progress in Retinal and Eye Research
  • 1 May 2004
The type of healing process that occurs in response to cataract surgery and intraocular lens (IOL) implantation is dependent on a complex set of variables. Their interactions determine whether or notExpand
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Role of p38 MAP kinase in regulation of cell migration and proliferation in healing corneal epithelium.
PURPOSE The purpose of the present study was to examine the roles of signaling pathways potentially activated by TGFbeta (i.e., Smad and p38 mitogen-activated kinase [MAPK]) in regulation of cellExpand
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  • Open Access
Snail is required for transforming growth factor-beta-induced epithelial-mesenchymal transition by activating PI3 kinase/Akt signal pathway.
Lens epithelial cells undergo epithelial-mesenchymal transition (EMT) after injury as in cataract extraction, leading to fibrosis of the lens capsule. We have previously shown that EMT of primaryExpand
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