In vitro effect of chromium and other trace metals on mouse hepatotoxicity induced by carbon tetrachloride exposure.
- M. Tezuka, S. Sadanobu, K. Gomi, M. Tachikawa, R. Sawamura
- Chemistry, MedicineBiological and Pharmaceutical Bulletin
- 15 February 1995
In vitro study suggested that Cr(III) contributes to protective effect on CCl4-induced hepatotoxicity, and the radical scavenger-like effect of the produced Cr( III) was the same effect as in vivo Cr(II).
In vitro tests of 1,3-dithia-2-thioxo-cyclopent-4-ene to evaluate the mechanisms of its hepatoprotective action.
- S. Sadanobu, M. Watanabe, C. Nakamura, M. Tezuka
- Biology, ChemistryJournal of Toxicological Sciences
- 20 December 1999
The protective effect of DT827A on a liver injury is due neither to its influence on liver GSH levels nor inhibition of the metabolic activation of CCl4, but a possible mechanism of action for theDT827 series of compounds to indicate an antioxidative effect would be brought about by the role of the compounds as a radical scavenger as well as its reductive effect.
Effect of 1,3-dithia-2-thioxo-cyclopent-4-ene and its derivatives on liver injury induced by carbon tetrachloride and orotic acid in rats.
- S. Sadanobu, M. Takeuchi, M. Tezuka
- Chemistry, BiologyJournal of Toxicological Sciences
- 15 December 1997
A hepatoprotective potential of theDT827 series compounds was suggested under the conditions of these studies, and DT827B was considered to be the most effective.
Effect of 4-phenyl-1,3-dithia-2-thioxo-cyclopent-4-ene on liver injury induced by repeated exposure to galactosamine plus carbon tetrachloride in rats.
A hepatoprotective potential of DT827B was suggested under the conditions of these studies after a therapeutic effect against liver injury induced by D-GalN + CCl4 dose-dependently was suggested.
Mutagenicity tests of 4-phenyl-1,3-dithia-2-thioxo-cyclopent-4-ene.
- S. Sadanobu, M. Holmstrom, C. Riach, I. A. Leddy, M. Tezuka
- BiologyJournal of Toxicological Sciences
- 10 May 1999
The mutagenicity of 4-phenyl-1,3-dithia-2-thioxo-cyclopent-4-ene was examined in reverse mutation tests, in the chromosomal aberration test with Chinese hamster ovary cells, and in the micronucleus test using mice bone-marrow, finding the increase in polyploidy probably is due to a toxic effect of the compound.