• Publications
  • Influence
In vitro effect of chromium and other trace metals on mouse hepatotoxicity induced by carbon tetrachloride exposure.
TLDR
In vitro study suggested that Cr(III) contributes to protective effect on CCl4-induced hepatotoxicity, and the radical scavenger-like effect of the produced Cr( III) was the same effect as in vivo Cr(II).
In vitro tests of 1,3-dithia-2-thioxo-cyclopent-4-ene to evaluate the mechanisms of its hepatoprotective action.
TLDR
The protective effect of DT827A on a liver injury is due neither to its influence on liver GSH levels nor inhibition of the metabolic activation of CCl4, but a possible mechanism of action for theDT827 series of compounds to indicate an antioxidative effect would be brought about by the role of the compounds as a radical scavenger as well as its reductive effect.
Effect of 1,3-dithia-2-thioxo-cyclopent-4-ene and its derivatives on liver injury induced by carbon tetrachloride and orotic acid in rats.
TLDR
A hepatoprotective potential of theDT827 series compounds was suggested under the conditions of these studies, and DT827B was considered to be the most effective.
Effect of 4-phenyl-1,3-dithia-2-thioxo-cyclopent-4-ene on liver injury induced by repeated exposure to galactosamine plus carbon tetrachloride in rats.
TLDR
A hepatoprotective potential of DT827B was suggested under the conditions of these studies after a therapeutic effect against liver injury induced by D-GalN + CCl4 dose-dependently was suggested.
Mutagenicity tests of 4-phenyl-1,3-dithia-2-thioxo-cyclopent-4-ene.
TLDR
The mutagenicity of 4-phenyl-1,3-dithia-2-thioxo-cyclopent-4-ene was examined in reverse mutation tests, in the chromosomal aberration test with Chinese hamster ovary cells, and in the micronucleus test using mice bone-marrow, finding the increase in polyploidy probably is due to a toxic effect of the compound.