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Synaptic and Extrasynaptic NMDA Receptors Are Gated by Different Endogenous Coagonists
N-methyl-d-aspartate receptors (NMDARs) are located in neuronal cell membranes at synaptic and extrasynaptic locations, where they are believed to mediate distinct physiological and pathologicalExpand
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Physiological functions of D-amino acid oxidases: from yeast to humans
Abstract.D-Amino acid oxidase (DAAO) is a FAD-containing flavoenzyme that catalyzes the oxidative deamination of D-isomers of neutral and polar amino acids. This enzymatic activity has beenExpand
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Glial D-serine gates NMDA receptors at excitatory synapses in prefrontal cortex.
N-methyl-D-aspartate receptors (NMDARs) subserve numerous neurophysiological and neuropathological processes in the cerebral cortex. Their activation requires the binding of glutamate and also of aExpand
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pLG72 Modulates Intracellular D-Serine Levels through Its Interaction with D-Amino Acid Oxidase
Human genes coding for pLG72 and d-amino acid oxidase have recently been linked to the onset of schizophrenia. pLG72 was proposed as an activator of the human FAD-containing flavoprotein d-amino acidExpand
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Characterization of human d‐amino acid oxidase
d‐Amino acid oxidase (DAAO) has been proposed to be involved in the oxidation of d‐serine, an allosteric activator of the NMDA‐type glutamate receptor in the brain, and to be associated with theExpand
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A filamentous cyanobacterium, belonging to the Order of Oscillatoriales, was found to be responsible for a toxic algal bloom in Lake Varese, Italy, during the summer of 1997. MorphologicalExpand
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Structure–function relationships in human d-amino acid oxidase
Since d-amino acids were identified in mammals, d-serine has been one of the most extensively studied “unnatural amino acids”. This brain-enriched transmitter-like molecule plays a pivotal role inExpand
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Properties and applications of microbial D-amino acid oxidases: current state and perspectives
D-Amino acid oxidase (DAAO) is a biotechnologically relevant enzyme that is used in a variety of applications. DAAO is a flavine adenine dinucleotide-containing flavoenzyme that catalyzes theExpand
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Identity of Endogenous NMDAR Glycine Site Agonist in Amygdala Is Determined by Synaptic Activity Level
Mechanisms of N-methyl-D-aspartate receptor-dependent synaptic plasticity contribute to the acquisition and retention of conditioned fear memory. However, synaptic rules which may determine theExpand
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Reduced D-serine levels in the nucleus accumbens of cocaine-treated rats hinder the induction of NMDA receptor-dependent synaptic plasticity.
Cocaine seeking behaviour and relapse have been linked to impaired potentiation and depression at excitatory synapses in the nucleus accumbens, but the mechanism underlying this process is poorlyExpand
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