• Publications
  • Influence
Antihistamine Agent Dimebon As a Novel Neuroprotector and a Cognition Enhancer
Abstract: Dimebon, launched earlier in Russia as an antihistamine drug, was evaluated as a representative of a new generation of anti‐Alzheimer's drugs that have two beneficial actions: (1) toExpand
  • 190
  • 13
Inhibition of monoamine oxidase A by beta-carboline derivatives.
beta-Carbolines are endogenous inhibitors of monoamine oxidase (MAO). The interaction of nine beta-carboline derivatives and four 3,4-dihydro forms with purified MAO A was investigated. All theExpand
  • 60
  • 9
Inhibition of Monoamine Oxidase A by β-Carboline Derivatives
β-Carbolines are endogenous inhibitors of monoamine oxidase (MAO). The interaction of nine β-carboline derivatives and four 3,4-dihydro forms with purified MAO A was investigated. All the compoundsExpand
  • 180
  • 7
Mitochondria as a Target for Neurotoxins and Neuroprotective Agents
Abstract: Mitochondrial permeability transition pores represent a multiprotein complex that includes components of both inner and outer membrane. The pores regulate transport of ions and peptides inExpand
  • 154
  • 5
  • PDF
Effect of Methylene Blue and Related Redox Dyes on Monoamine Oxidase Activity; Rat Pineal Content of N‐Acetylserotonin, Melatonin, and Related Indoles; and Righting Reflex in Melatonin‐Primed Frogs
The ability of methylene blue (MB) to inhibit the nitric oxide–induced stimulation of N‐methyl‐d‐aspartate receptors has been suggested as a possible mechanism of MB's clinical antidepressant action.Expand
  • 23
  • 3
Characterization of the inhibitory mechanism of 1-methyl-4-phenylpyridinium and 4-phenylpyridine analogs in inner membrane preparations.
We have investigated the mechanism of the inhibition of membrane-bound NADH dehydrogenase by 1-methyl-4-phenylpyridinium (MPP+) and a series of its 4'-alkyl-substituted analogs of increasingExpand
  • 80
  • 1
Inhibition of complex I by hydrophobic analogues of N-methyl-4-phenylpyridinium (MPP+) and the use of an ion-selective electrode to measure their accumulation by mitochondria and electron-transport
N-methyl-4-phenylpyridinium (MPP+), the neurotoxic metabolite of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, kills dopaminergic neurons after its accumulation in mitochondria where it inhibitsExpand
  • 27
  • 1
Monoamine Oxidase Contains a Redox-active Disulfide*
Mitochondrial monoamine oxidases A and B (MAO A and MAO B) are ubiquitous homodimeric FAD-containing oxidases that catalyze the oxidation of biogenic amines. Both enzymes play a vital role in theExpand
  • 19
  • PDF
Inhibitor Probes of the Quinone Binding Sites of Mammalian Complex II and Escherichia coli Fumarate Reductase*
The structural and catalytic properties of beef heart succinate dehydrogenase (succinate-ubiquinone oxidoreductase, complex II) and Escherichia coli fumarate reductase are remarkably similar. OneExpand
  • 36
Substrates but not inhibitors alter the redox potentials of monoamine oxidases.
The midpoint potentials for the reduction of the cysteinyl-flavin adenine dinucleotide (FAD) in monoamine oxidases (MAO) A and B in the absence and presence of ligands have been determined. Both MAOExpand
  • 11