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Phenotypic stability of bovine articular chondrocytes after long-term culture in alginate beads.
TLDR
It is shown that chondrocytes isolated from the full depth of adult bovine articular cartilage and maintained for 8 months in alginate gel are still metabolically active and continue to synthesize cartilage-specific type II collagen and aggrecan.
Biochemical aspects of the neuroprotective mechanism of PTEN‐induced kinase‐1 (PINK1)
TLDR
A model on the neuroprotective mechanism of PINK1 is proposed and may serve as a conceptual framework for future investigation into the molecular basis of PD pathogenesis.
C-terminal truncation and Parkinson's disease-associated mutations down-regulate the protein serine/threonine kinase activity of PTEN-induced kinase-1.
TLDR
The availability of active recombinant Pink1 proteins permits future studies to search for mitochondrial proteins that are preferentially phosphorylated by PINK1, and sheds light on the mechanism of pathogenesis of PD.
Adult human chondrocytes cultured in alginate form a matrix similar to native human articular cartilage.
TLDR
Results add support to the contention that aggrecan molecules residing in the pericellular and territorial areas of the adult human articular cartilage matrix are more susceptible to degradation by proteolytic enzymes synthesized by the chondrocytes than those that inhabit the interterritorial areas further removed from the cells.
A comparative analysis of leucine-rich repeat kinase 2 (Lrrk2) expression in mouse brain and Lewy body disease
TLDR
A role for Lrrk2 in neurogenesis might provide further insight into the aberrant role of mutant protein in age-associated neurodegeneration with pleomorphic pathology.
Aggrecan synthesized by mature bovine chondrocytes suspended in alginate. Identification of two distinct metabolic matrix pools.
TLDR
Results strongly suggest aggrecan molecules which reside in the pericellular and territorial matrix compartments in close proximity to the chondrocytes have a much faster rate of turnover than their counterpart in the interterritorial areas further removed from the cells.
Identification of potential protein interactors of Lrrk2.
TLDR
14 potential Lrrk2 binding partners are identified and the majority of these interactions may be subgrouped into three functional cellular pathways: (i) chaperone-mediated response, (ii) proteins associated with the cytoskeleton and trafficking and (iii) phosphorylation and kinase activity.
Expression and analysis of heparin‐binding regions of the amyloid precursor protein of Alzheimer's disease
TLDR
This study suggests that heparin‐binding domains may lie within regions high in α‐helical structure in the presence of heparan sulphate.
α-Synuclein Transgenic Mice Reveal Compensatory Increases in Parkinson's Disease-Associated Proteins DJ-1 and Parkin and Have Enhanced α-Synuclein and PINK1 Levels After Rotenone Treatment
TLDR
These hA53T αSN transgenic mice provide a useful model for presymptomatic Parkinson's features and are valuable for study of associated compensatory changes in early Parkinson's disease stages.
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