Share This Author
The anti-neoplastic and novel topoisomerase II-mediated cytotoxicity of neoamphimedine, a marine pyridoacridine.
Mechanism of ascididemin-induced cytotoxicity.
- S. S. Matsumoto, J. Biggs, B. Copp, J. Holden, L. Barrows
- Biology, ChemistryChemical research in toxicology
- 1 February 2003
Experimental results supported direct iminoquinone reduction and ROS generation as the mechanism of ascididemin cytotoxicity and demonstrated that cells deficient in the ability to repair reactive oxygen species damage to their DNA were more susceptible to asciddemin and analogues than repair competent cells.
Cell adhesion mechanisms: modeling using derivatized beads and sea urchin cell systems.
Neoamphimedine: A New Pyridoacridine Topoisomerase II Inhibitor Which Catenates DNA
Makaluvamine N: a new pyrroloiminoquinone from Zyzzya fuliginosa.
- D. Venables, G. Concepcion, S. S. Matsumoto, L. Barrows, C. Ireland
- ChemistryJournal of natural products
- 1 April 1997
A new pyrroloiminoquinone was isolated from the Philippine sponge Zyzzya fuliginosa and demonstrated an ability to inhibit the catalytic activity of topoisomerase II.
Mechanism of action studies of cytotoxic marine alkaloids: ascididemin exhibits thiol-dependent oxidative DNA cleavage
Makaluvamines vary in ability to induce dose-dependent DNA cleavage via topoisomerase II interaction.
For most of the makaluvamines the levels of cleavage are significantly below those achieved by equimolar concentrations of etoposide, so to some extent these results might explain the discrepancies present in the literature.