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Monoamine oxidase‐B in astrocytes
- J. Ekblom, S. S. Jossan, Mats Bergstrüm, L. Oreland, E. Walum, S. Aquilonius
- Biology, MedicineGlia
- 1 June 1993
Astrocytic localization and content of monoamine oxidase‐B (MAO‐B) is described by means of a 3H‐L‐deprenyl emulsion autoradiography in primary cultures of rat astrocytes, in cryosections of human spinal cords from patients dying in amyotrophic lateral sclerosis (ALS) and controls.
Insulin-like growth factor 1 (IGF-1) receptors in the human brain: quantitative autoradiographic localization
Quantitative localization of human brain monoamine oxidase B by large section autoradiography using l-[3H]deprenyl
Monoamine oxidase B in brains from patients with Alzheimer's disease: A biochemical and autoradiographical study
Double blind cross over trial with deprenyl in amyotrophic lateral sclerosis.
- S. S. Jossan, J. Ekblom, O. Gudjonsson, K. Hagbarth, S. Aquilonius
- Medicine, PsychologyJournal of neural transmission. Supplementum
Deprenyl treatment in 10 patients suffering from amyotrophic lateral sclerosis observed that all cases deteriorated in their clinical status during the 36 weeks of the controlled study, and MAO-B activity in blood platelets was completely inhibited during treatment with deprenyl.
Characterisation of dopamine and serotonin uptake inhibitory effects of tetrahydroaminoacridine in rat brain.
- S. S. Jossan, A. Adem, B. Winblad, L. Oreland
- Biology, ChemistryPharmacology & toxicology
- 1 September 1992
The results show that THA is a non-competitive uptake inhibitor of dopamine and 5-HT in the nerve terminals, which might lead to increased levels of these monoamines in brains of Alzheimer patients and contribute in the therapeutic effects of the drug.
MPTP toxicity in relation to age, dopamine uptake and MAO-B activity in two rodent species.
No obvious correlations were found either between MAO-B activities or DA uptake rates and the neurotoxic effect of MPTP, and no neurotoxicity of single dose MPTP treatment was observed in the rats, irrespective of their age.
Quantitative autoradiography of nicotinic receptors in large cryosections of human brain hemispheres
Tetrahydroaminoacridine inhibits human and rat brain monoamine oxidase
Reactive gliosis and monoamine oxidase B.
- J. Ekblom, S. S. Jossan, L. Oreland, E. Walum, S. Aquilonius
- BiologyJournal of neural transmission. Supplementum
In the ALS spinal cords an increased number of astrocytes as well as an increased content of MAO-B in reactive species of ast rocytes was demonstrated and a sub-population of reactive astroCytes that contained low levels of MAo-B was observed in spinal sections.