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Age- and sex-specific incidence of childhood leukemia by immunophenotype in the Nordic countries.
BACKGROUND Studies from various countries have found an increasing incidence of childhood leukemia in recent decades. To characterize time trends in the age- and sex-specific incidence of childhoodExpand
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Genome-wide signatures of differential DNA methylation in pediatric acute lymphoblastic leukemia
BackgroundAlthough aberrant DNA methylation has been observed previously in acute lymphoblastic leukemia (ALL), the patterns of differential methylation have not been comprehensively determined inExpand
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Beneficial effect of long term intravenous bisphosphonate treatment of osteogenesis imperfecta
Aim: To find an effective symptomatic treatment for osteogenesis imperfecta (OI). Methods: In a prospective observational study disodium pamidronate (APD) was given as monthly intravenous infusionsExpand
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Prognostic importance of p15INK4B and p16INK4 gene inactivation in childhood acute lymphocytic leukemia.
PURPOSE The present study explores the prognostic importance of p16INK4/p15INK4B gene inactivation in childhood acute lymphocytic leukemia (ALL). MATERIALS AND METHODS Cells from 79 pediatric ALLExpand
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Spectral karyotyping and interphase FISH reveal abnormalities not detected by conventional G‐banding
Abstract: Seventy uniformly treated children with acute lymphoblastic leukemia were analysed for chromosomal abnormalities with conventional G‐banding, spectral karyotyping (SKY) and interphaseExpand
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No osteonecrosis in jaws of young patients with osteogenesis imperfecta treated with bisphosphonates.
BACKGROUND Recent reports of osteonecrosis of the jaw (ONJ) after dental surgery in patients treated with second- and third-generation nitrogen-containing bisphosphonates instigated thisExpand
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Chronic lymphocytic leukemia cells with allelic deletions at 13q14 commonly have one intact RB1 gene: evidence for a role of an adjacent locus.
We have previously shown that 30% of patients with B-cell chronic lymphocytic leukemia (B-CLL) have hemizygous deletions of the retinoblastoma (RB1) gene at 13q14. RB1 gene deletions may thusExpand
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Overexpression of CD123 correlates with the hyperdiploid genotype in acute lymphoblastic leukemia
This study on patients with acute lymphoblastic leukemia (ALL) shows that overexpression of CD123 is an aberrant phenotype present in a subset of precursor-B ALL with hyperdiploid genotype, andExpand
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High white blood cell count at diagnosis of childhood acute lymphoblastic leukaemia: biological background and prognostic impact. Results from the NOPHO ALL‐92 and ALL‐2000 studies
Prognostic impact of peripheral blood white blood cell count (WBC) at the diagnosis of childhood acute lymphoblastic leukaemia (ALL) was evaluated in a population‐based consecutive series of 2666Expand
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DNA ligases of eukaryotes
DNA ligases [poly(deoxytibonucleotide): poly(deoxyribonucleotide) ligase EC 6.5.1] join single-strand breaks in double-stranded DNA by catalyzing the formation of phosphodiester bonds. These enzymesExpand
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