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Tolerogenic dendritic cells: cytokine modulation comes of age.
Dendritic cells (DCs) include a heterogeneous family of professional APCs involved in initiation of immunity and in immunologic tolerance. Specifically, peripheral tolerance can be achieved and… Expand
Mobilization of bone marrow-derived stem cells after myocardial infarction and left ventricular function.
AIMS Recent data suggest that the administration of bone marrow-derived stem cells (BMSC) might improve myocardial perfusion and left ventricular (LV) function after acute myocardial infarction… Expand
Modulation of tryptophan catabolism by human leukemic cells results in the conversion of CD25- into CD25+ T regulatory cells.
Indoleamine 2,3-dioxygenase (IDO) is a novel immunosuppressive agent expressed in some subsets of normal and neoplastic cells, including acute myeloid leukemia (AML) cells. Here, we show that IDO… Expand
Expression of CD133-1 and CD133-2 in ovarian cancer
- G. Ferrandina, G. Bonanno, +10 authors G. Scambia
- Medicine, Biology
- International Journal of Gynecologic Cancer
- 25 June 2007
Cancer stem cells have been isolated from several solid tumors including prostate, colon, liver, breast, and ovarian cancer. Stem cells isolated from nervous system and prostate express CD133… Expand
Angiogenesis as a novel component of inflammatory bowel disease pathogenesis.
BACKGROUND & AIMS Angiogenesis is a critical component of neoplastic and chronic inflammatory disorders, but whether angiogenesis also occurs in inflammatory bowel disease (IBD) has yet to be… Expand
HLA-haploidentical stem cell transplantation after removal of αβ+ T and B cells in children with nonmalignant disorders.
Twenty-three children with nonmalignant disorders received HLA-haploidentical hematopoietic stem cell transplantation (haplo-HSCT) after ex vivo elimination of αβ(+) T cells and CD19(+) B cells. The… Expand
Cells with Characteristics of Cancer Stem/Progenitor Cells Express the CD133 Antigen in Human Endometrial Tumors
- S. Rutella, G. Bonanno, +12 authors G. Ferrandina
- Biology, Medicine
- Clinical Cancer Research
- 1 July 2009
Purpose: Cancer stem cells represent an attractive therapeutic target for tumor eradication. The present study aimed to determine whether CD133 expression may identify cells with characteristics of… Expand
Hepatocyte growth factor favors monocyte differentiation into regulatory interleukin (IL)-10++IL-12low/neg accessory cells with dendritic-cell features.
Several hematopoietic growth factors, including interleukin-10 (IL-10) and transforming growth factor-beta1 (TGF-beta1), promote the differentiation of tolerogenic dendritic cells (DCs). Hepatocyte… Expand
Association between cutaneous melanoma, Breslow thickness and vitamin D receptor BsmI polymorphism
- C. Santonocito, R. Capizzi, +11 authors E. Capoluongo
- The British journal of dermatology
- 1 February 2007
Summary Background Literature data report an association between some vitamin D receptor (VDR) polymorphisms and different kinds of tumours, including malignant melanoma (MM). Only three VDR… Expand
Anti-HIV Effects of Chloroquine: Inhibition of Viral Particle Glycosylation and Synergism With Protease Inhibitors
- A. Savarino, M. B. Lucia, +8 authors R. Cauda
- Medicine, Biology
- Journal of acquired immune deficiency syndromes
- 1 March 2004
ObjectiveWe tested the effects of chloroquine (CQ) on glycosylation of HIV particles and in combination with protease inhibitors (PIs) on HIV replication and on P-glycoprotein (P-gp)/multidrug… Expand