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Engineering targeted viral vectors for gene therapy
To achieve therapeutic success, transfer vehicles for gene therapy must be capable of transducing target cells while avoiding impact on non-target cells. Despite the high transduction efficiency of… Expand
The epidemiology of dog walking: an unmet need for human and canine health
Photograph: The second author, a dog‐walking advocate, involved in field work and formative research which led to the generation of the research question in this study.
Application of life cycle assessment to sheep production systems: investigating co-production of wool and meat using case studies from major global producers
- S. Wiedemann, S. Ledgard, B. Henry, Ming-Jia Yan, N. Mao, S. Russell
- The International Journal of Life Cycle…
- 28 January 2015
PurposeMethodology of co-product handling is a critical determinant of calculated resource use and environmental emissions per kilogram (kg) product but has not been examined in detail for different… Expand
Identifying the generic limits of the Cheilanthoid genus Doryopteris
Morphology-based delimitation of genera in the Cheilanthoid ferns has proved to be problematic and understanding of the phylogeny and relationships amongst Cheilanthoid ferns based on morphological… Expand
Climate, Colonisation and Celibacy: Population Structure in Central European Trichomanes speciosum (Pteridophyta)
: The Killarney fern Trichomanes speciosum Willd. (Hymenophyllaceae) is unique in possessing both extensive sexual (sporophyte and gametophyte generations present) and asexual (gametophyte only)… Expand
Structural analysis of bacterial ABC transporter inhibition by an antibody fragment.
Bacterial ATP-binding cassette (ABC) importers play critical roles in nutrient acquisition and are potential antibacterial targets. However, structural bases for their inhibition are poorly defined.… Expand
Phase I trial of Intraperitoneal (IP) administration of a measles virus (MV) derivative expressing the human carcinoembryonic antigen (CEA) in recurrent ovarian cancer (OvCa)
5538 Background: Edmonston vaccine strains of MV have significant antitumor activity against OvCa xenografts (Peng et al, Cancer Res, 2002). Oncolytic selectivity is due to overexpression of the MV… Expand
Medical indications for splenectomy.
The spleen, whether anatomically and physiologically normal or diseased, may significantly worsen the clinical picture in a variety of medical disorders. However, splenectomy should be undertaken… Expand
Structure-property-function relationships in triple helical collagen hydrogels
In order to establish defined biomimetic systems, type I collagen was functionalised with 1,3-Phenylenediacetic acid (Ph) as aromatic, bifunctional segment. Following investigation on molecular… Expand
Population structure and conservation biology of the endangered fern Trichomanes speciosum Willd. (Hymenophyllaceae) at its northern distributional limit
Abstract Genetic diversity in the Killarney fern, Trichomanes speciosum Willd. has been investigated in south-western Scotland, the northern-most limit of the distribution of the sporophyte. T.… Expand