• Publications
  • Influence
Blockage by Adenovirus E4orf6 of Transcriptional Activation by the p53 Tumor Suppressor
The adenovirus E4orf6 protein is shown here to interact with the cellular tumor suppressor protein p53 and to block p53-mediated transcriptional activation. The adenovirus protein inhibited theExpand
  • 317
  • 18
Structural analysis of the adenovirus type 5 E1B 55-kilodalton-E4orf6 protein complex.
The adenovirus type 5 (Ad5) early 1B (E1B) 55-kDa (E1B-55kDa)-E4orf6 protein complex has been implicated in the selective modulation of nucleocytoplasmic mRNA transport at late times after infection.Expand
  • 104
  • 10
The adenovirus E4orf6 protein can promote E1A/E1B-induced focus formation by interfering with p53 tumor suppressor function.
We have recently shown that the adenovirus type 5 E4orf6 protein interacts with the cellular tumor suppressor protein p53 and blocks p53 transcriptional functions. Here we report that the E4orf6Expand
  • 134
  • 3
Two Distinct Activities Contribute to the Oncogenic Potential of the Adenovirus Type 5 E4orf6 Protein
ABSTRACT Previous studies have shown that the adenovirus type 5 (Ad5) E4orf6 gene product displays features of a viral oncoprotein. It initiates focal transformation of primary rat cells inExpand
  • 51
  • 3
  • Open Access